Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACJWMD_RS04120 Genome accession   NZ_CP177182
Coordinates   905557..906231 (+) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus salivarius strain MRD6060     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 900557..911231
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMD_RS04100 - 901677..902249 (-) 573 WP_004182389.1 ECF transporter S component -
  ACJWMD_RS04105 coaC 902278..902823 (-) 546 WP_004182390.1 phosphopantothenoylcysteine decarboxylase -
  ACJWMD_RS04110 - 902816..903494 (-) 679 Protein_755 phosphopantothenate--cysteine ligase -
  ACJWMD_RS04115 - 903689..905359 (+) 1671 WP_004182072.1 formate--tetrahydrofolate ligase -
  ACJWMD_RS04120 ciaR 905557..906231 (+) 675 WP_002891134.1 response regulator transcription factor Regulator
  ACJWMD_RS04125 ciaH 906221..907636 (+) 1416 WP_004182392.1 sensor histidine kinase Regulator
  ACJWMD_RS04130 rpsT 907714..907950 (-) 237 WP_004182129.1 30S ribosomal protein S20 -
  ACJWMD_RS04135 coaA 908020..908940 (-) 921 WP_004182393.1 type I pantothenate kinase -
  ACJWMD_RS04140 - 909053..909643 (+) 591 WP_004182394.1 class I SAM-dependent methyltransferase -
  ACJWMD_RS04145 - 909640..910917 (+) 1278 WP_004182395.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=1086009 ACJWMD_RS04120 WP_002891134.1 905557..906231(+) (ciaR) [Streptococcus salivarius strain MRD6060]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1086009 ACJWMD_RS04120 WP_002891134.1 905557..906231(+) (ciaR) [Streptococcus salivarius strain MRD6060]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTAATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362

Multiple sequence alignment