Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACJVC4_RS06125 Genome accession   NZ_CP177179
Coordinates   1240028..1240702 (-) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus salivarius strain MRD-NRLLH     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1235028..1245702
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJVC4_RS06100 - 1235334..1236611 (-) 1278 WP_002891129.1 pyrimidine-nucleoside phosphorylase -
  ACJVC4_RS06105 - 1236608..1237198 (-) 591 WP_002891130.1 class I SAM-dependent methyltransferase -
  ACJVC4_RS06110 coaA 1237312..1238232 (+) 921 WP_037597889.1 type I pantothenate kinase -
  ACJVC4_RS06115 rpsT 1238302..1238538 (+) 237 WP_037597891.1 30S ribosomal protein S20 -
  ACJVC4_RS06120 ciaH 1238623..1240038 (-) 1416 WP_002891133.1 sensor histidine kinase Regulator
  ACJVC4_RS06125 ciaR 1240028..1240702 (-) 675 WP_002891134.1 response regulator transcription factor Regulator
  ACJVC4_RS06130 - 1240901..1242571 (-) 1671 WP_002891135.1 formate--tetrahydrofolate ligase -
  ACJVC4_RS06135 - 1242766..1243449 (+) 684 WP_002891136.1 phosphopantothenate--cysteine ligase -
  ACJVC4_RS06140 coaC 1243442..1243987 (+) 546 WP_004182014.1 phosphopantothenoylcysteine decarboxylase -
  ACJVC4_RS06145 - 1244016..1244588 (+) 573 WP_037597893.1 ECF transporter S component -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=1085807 ACJVC4_RS06125 WP_002891134.1 1240028..1240702(-) (ciaR) [Streptococcus salivarius strain MRD-NRLLH]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1085807 ACJVC4_RS06125 WP_002891134.1 1240028..1240702(-) (ciaR) [Streptococcus salivarius strain MRD-NRLLH]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGACGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGCGAAAAAGGTGTAACGACTCCTGTTCTTATCATGACGGCA
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGGGCAGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TTAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACTACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362

Multiple sequence alignment