Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   ACK0E3_RS12030 Genome accession   NZ_CP176473
Coordinates   2484780..2486972 (-) Length   730 a.a.
NCBI ID   WP_411163392.1    Uniprot ID   -
Organism   Lacticaseibacillus paracasei strain BBM398     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2487766..2497889 2484780..2486972 flank 794


Gene organization within MGE regions


Location: 2484780..2497889
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACK0E3_RS12030 comA 2484780..2486972 (-) 2193 WP_411163392.1 peptide cleavage/export ABC transporter Regulator
  ACK0E3_RS12035 - 2487439..2487576 (-) 138 WP_003571414.1 bacteriocin-like peptide, LSEI_2386 family -
  ACK0E3_RS12040 - 2487766..2489063 (+) 1298 Protein_2345 GHKL domain-containing protein -
  ACK0E3_RS12045 - 2489068..2489874 (+) 807 WP_218209512.1 LytR/AlgR family response regulator transcription factor -
  ACK0E3_RS12050 - 2490236..2490433 (-) 198 WP_042753684.1 hypothetical protein -
  ACK0E3_RS12055 - 2490980..2491219 (+) 240 WP_218209511.1 hypothetical protein -
  ACK0E3_RS12060 - 2491493..2491666 (-) 174 WP_013246049.1 bacteriocin -
  ACK0E3_RS12065 - 2491705..2491878 (-) 174 WP_013246050.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ACK0E3_RS12070 - 2492200..2492424 (+) 225 WP_218209510.1 hypothetical protein -
  ACK0E3_RS12075 - 2493224..2494036 (-) 813 WP_218209509.1 CPBP family intramembrane glutamic endopeptidase -
  ACK0E3_RS12080 - 2494320..2494478 (-) 159 WP_003599805.1 hypothetical protein -
  ACK0E3_RS12085 - 2494594..2494926 (-) 333 WP_003599808.1 hypothetical protein -
  ACK0E3_RS12090 - 2495177..2495368 (-) 192 WP_013246055.1 hypothetical protein -
  ACK0E3_RS12095 - 2495680..2496015 (-) 336 WP_003599812.1 bacteriocin immunity protein -
  ACK0E3_RS12100 - 2496134..2496729 (-) 596 Protein_2357 sugar O-acetyltransferase -
  ACK0E3_RS12105 - 2497000..2497308 (-) 309 WP_218209508.1 hypothetical protein -
  ACK0E3_RS12110 - 2497444..2497659 (-) 216 WP_003567374.1 hypothetical protein -
  ACK0E3_RS12115 - 2497656..2497889 (-) 234 WP_003567376.1 Blp family class II bacteriocin -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81358.66 Da        Isoelectric Point: 7.2448

>NTDB_id=1080296 ACK0E3_RS12030 WP_411163392.1 2484780..2486972(-) (comA) [Lacticaseibacillus paracasei strain BBM398]
MIKYNIKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAKALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKVDQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHTELLAK
QGYYARLVSE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=1080296 ACK0E3_RS12030 WP_411163392.1 2484780..2486972(-) (comA) [Lacticaseibacillus paracasei strain BBM398]
ATGATCAAATACAACATAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAATTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTAAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCACCAGAACCGCAATATCAACCACGCAAAGAGGAT
AAAGGCAGTCTTTTTGCGTTTGTGCCGATGCTGGCGCGGCAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTATT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTTGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAGATTGTATCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACTTATTTGAAAAAGTCGTTCAATTATACAAAAGTTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTGACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCCATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCAATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATACTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(510-662)

ABC transporter transmembrane region (ABC_membrane)

(180-448)

Peptidase C39 family (Peptidase_C39)

(16-152)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

58.635

98.356

0.577
  comA Streptococcus pneumoniae Rx1

58.078

98.356

0.571
  comA Streptococcus pneumoniae D39

58.078

98.356

0.571
  comA Streptococcus pneumoniae R6

58.078

98.356

0.571
  comA Streptococcus mitis SK321

57.939

98.356

0.57
  comA Streptococcus pneumoniae TIGR4

57.66

98.356

0.567
  comA Streptococcus gordonii str. Challis substr. CH1

57.103

98.356

0.562
  comA/nlmT Streptococcus mutans UA159

55.125

98.904

0.545

Multiple sequence alignment