Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACAM22_RS05635 Genome accession   NZ_AP028929
Coordinates   1273968..1274642 (-) Length   224 a.a.
NCBI ID   WP_369606496.1    Uniprot ID   A0AAT9G1A2
Organism   Streptococcus sp. SN-1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1268968..1279642
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM22_RS05630 (MASAN616_11080) ciaH 1272644..1273978 (-) 1335 WP_369606495.1 two-component system sensor histidine kinase CiaH Regulator
  ACAM22_RS05635 (MASAN616_11090) ciaR 1273968..1274642 (-) 675 WP_369606496.1 two-component system response regulator CiaR Regulator
  ACAM22_RS05640 (MASAN616_11100) - 1274857..1277403 (-) 2547 WP_369606497.1 M1 family metallopeptidase -
  ACAM22_RS05645 (MASAN616_11110) - 1277524..1277964 (-) 441 WP_261050081.1 ASCH domain-containing protein -
  ACAM22_RS05650 (MASAN616_11120) - 1277906..1278808 (-) 903 WP_261050412.1 putative PEP-binding protein -
  ACAM22_RS05655 (MASAN616_11130) - 1278786..1278926 (-) 141 Protein_1121 NUDIX hydrolase -
  ACAM22_RS05660 (MASAN616_11140) - 1278937..1279635 (-) 699 WP_261050083.1 3-oxoacyl-ACP reductase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=107331 ACAM22_RS05635 WP_369606496.1 1273968..1274642(-) (ciaR) [Streptococcus sp. SN-1]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENSLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=107331 ACAM22_RS05635 WP_369606496.1 1273968..1274642(-) (ciaR) [Streptococcus sp. SN-1]
ATGATAAAAATCTTATTGGTTGAGGATGACTTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCAGATGT
CATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGCGTCTATGACTTGATTTTGCTCGATTTGATGT
TACCTGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACACGGATTTGAATTGGGAGCGGATGATTATTTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGTAAATTTAATGAAAACAGCTTGACTTATGGAAATATTGTAG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTTGATTTACTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGACACAACAAT
TTCAGTTGTCGAAGTCTATGTTTCAAAAATTCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

98.661

100

0.987
  ciaR Streptococcus pneumoniae D39

98.661

100

0.987
  ciaR Streptococcus pneumoniae R6

98.661

100

0.987
  ciaR Streptococcus pneumoniae Rx1

98.661

100

0.987
  ciaR Streptococcus mutans UA159

89.286

100

0.893
  vicR Streptococcus mutans UA159

35.622

100

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.444

100

0.366

Multiple sequence alignment