Detailed information NTG0107330

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: ACAM22_RS05630
• Genome accession: NZ_AP028929
• Coordinates: 1272644..1273978 (-)
• Length: 444 a.a.
• NCBI ID: WP_369606495.1
• Uniprot ID: A0AAT9G0X9
• Organism: Streptococcus sp. SN-1
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1267644..1278978

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACAM22_RS05625 (MASAN616_11070)	-	1268887..1272387 (-)	3501	WP_369606494.1	pneumococcal-type histidine triad protein	-
ACAM22_RS05630 (MASAN616_11080)	ciaH	1272644..1273978 (-)	1335	WP_369606495.1	two-component system sensor histidine kinase CiaH	Regulator
ACAM22_RS05635 (MASAN616_11090)	ciaR	1273968..1274642 (-)	675	WP_369606496.1	two-component system response regulator CiaR	Regulator
ACAM22_RS05640 (MASAN616_11100)	-	1274857..1277403 (-)	2547	WP_369606497.1	M1 family metallopeptidase	-
ACAM22_RS05645 (MASAN616_11110)	-	1277524..1277964 (-)	441	WP_261050081.1	ASCH domain-containing protein	-
ACAM22_RS05650 (MASAN616_11120)	-	1277906..1278808 (-)	903	WP_261050412.1	putative PEP-binding protein	-
ACAM22_RS05655 (MASAN616_11130)	-	1278786..1278926 (-)	141	Protein_1121	NUDIX hydrolase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50748.47 Da
• Isoelectric Point: 9.1616

>NTDB_id=107330 ACAM22_RS05630 WP_369606495.1 1272644..1273978(-) (ciaH) [Streptococcus sp. SN-1]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAILINTSQLEQASQKHEKLIVIVMTSFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=107330 ACAM22_RS05630 WP_369606495.1 1272644..1273978(-) (ciaH) [Streptococcus sp. SN-1]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTACTTTATTCGCAACTTCGGTGTCTTCACTCTGAT
TTTCTCCACCATGACCTTGATTATTTTACAGGTCATGCATTCGAGTCTTTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTGGCAGTGAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCTGCC
ACAGATACTAGCAAGACTGAGGTGAAACCCAATGTCAGTTCTAACACAGAAGTCATTCTTTTTGATAAAAATTTTACCCA
ACTCCTTTCTGGAAATCGATTTTTGGGATTGGATAAAATTAAGTTAGAAAAGAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATATTGATGGAAACCAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCAGCTATCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCACGAGAAATTGATTGTGATTGT
GATGACAAGTTTCTGGATTTTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGGCCCCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTCGTGGAAAATGCCAGTCATGAGTTACGAACCCCACTTGCAGTTCTGCAAAATCGTTTAGAG
ACCCTTTTCCGTAAGCCGGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCCTCTAGTTTAGAAGAAGTCCGAAATAT
GCGTTTTTTGACAACAAACTTGTTGAACTTAGCTCGTAGAGATGATGGCATTAAGCCAGAACTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGGATT
CATCGCACGATTGTCACAGACCAGCTTCTTCTGAAACAACTGATGACCATCTTATTTGATAATGCTGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTGTATTTACTTGTTTCTGATAATGGAGTCGGTA
TTTCGACAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGACAAGGCTAGAACCCGCCAAAAAGGTGGATTT
GGTTTAGGATTATCTCTGGCCAAGCAAATTGTAGATGCGCTTAAAGGAACCATTACTGTTAAAGATAATAAACCAAAGGG
AACAATCTTTGAAGTGAAGATTGCTATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	96.171	100	0.962
ciaH	Streptococcus pneumoniae D39	96.171	100	0.962
ciaH	Streptococcus pneumoniae R6	96.171	100	0.962
ciaH	Streptococcus pneumoniae TIGR4	96.171	100	0.962
ciaH	Streptococcus mutans UA159	55.862	97.973	0.547