Detailed information NTG1069122

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACF1RT_RS10315
• Genome accession: NZ_CP172847
• Coordinates: 2070890..2072098 (+)
• Length: 402 a.a.
• NCBI ID: WP_002262650.1
• Uniprot ID: Q8DRQ6
• Organism: Streptococcus mutans strain DPC6143
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2065890..2077098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACF1RT_RS10305 (ACF1RT_10305)	-	2069200..2069862 (-)	663	WP_002262652.1	YoaK family protein	-
ACF1RT_RS10310 (ACF1RT_10310)	rlmH	2070205..2070684 (-)	480	WP_002262651.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACF1RT_RS10315 (ACF1RT_10315)	htrA	2070890..2072098 (+)	1209	WP_002262650.1	S1C family serine protease	Regulator
ACF1RT_RS10320 (ACF1RT_10320)	spo0J	2072576..2073346 (+)	771	WP_032506325.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 402 a.a.
• Molecular weight: 43071.55 Da
• Isoelectric Point: 8.8092

>NTDB_id=1069122 ACF1RT_RS10315 WP_002262650.1 2070890..2072098(+) (htrA) [Streptococcus mutans strain DPC6143]
MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQK
TDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAV
IKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSG
GALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKI
PSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDL
NH

Nucleotide

• Length: 1209 bp

>NTDB_id=1069122 ACF1RT_RS10315 WP_002262650.1 2070890..2072098(+) (htrA) [Streptococcus mutans strain DPC6143]
GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGT
CATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCA
TTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAA
ACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGA
AGGTTCTGGTGTTATCTATAAAAAAGATGGCGATAGTGCTTATTTAGTTACAAACAATCATGTCGTTAAAGATGCAGAAA
AGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTT
ATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAAT
CGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAA
CTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGT
GGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGG
CGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTG
AAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATA
CCAAGTGATGTCACAAGCGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTGAAGAAATATGA
TGTCATTACAGAAATTGATGGGAAGAAGGTAGCGTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAG
ATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTG
AATCATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (298-393)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• Peptidase family M50 (Peptidase_M50) (227-398)

3D structure

• AlphaFold DB: Q8DRQ6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	100	100	1
htrA	Streptococcus gordonii str. Challis substr. CH1	56.14	99.254	0.557
htrA	Streptococcus mitis NCTC 12261	54.684	98.259	0.537
htrA	Streptococcus pneumoniae Rx1	54.315	98.01	0.532
htrA	Streptococcus pneumoniae D39	54.315	98.01	0.532
htrA	Streptococcus pneumoniae R6	54.315	98.01	0.532
htrA	Streptococcus pneumoniae TIGR4	54.315	98.01	0.532