Detailed information NTG0106416

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AABA19_RS02550
• Genome accession: NZ_AP028609
• Coordinates: 499130..499867 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain Sep4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 494130..504867

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA19_RS02520 (TKY121806_04930)	-	495462..495749 (-)	288	WP_000777760.1	hypothetical protein	-
AABA19_RS02525 (TKY121806_04940)	-	495759..496169 (-)	411	WP_050282188.1	HIT family protein	-
AABA19_RS02530 (TKY121806_04950)	pptA	496237..496968 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
AABA19_RS02535 (TKY121806_04960)	-	496965..498014 (+)	1050	WP_050154083.1	ABC transporter permease	-
AABA19_RS02540 (TKY121806_04970)	-	498182..498511 (-)	330	WP_000132575.1	hypothetical protein	-
AABA19_RS02545 (TKY121806_04980)	-	498787..499125 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
AABA19_RS02550 (TKY121806_04990)	comE/blpR	499130..499867 (+)	738	WP_001219120.1	response regulator transcription factor	Regulator
AABA19_RS02555 (TKY121806_05000)	-	499881..501221 (+)	1341	WP_001017646.1	sensor histidine kinase	-
AABA19_RS02560 (TKY121806_05010)	blpC	501292..501420 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
AABA19_RS02565 (TKY121806_05020)	-	501477..502838 (-)	1362	WP_338171499.1	bacteriocin secretion accessory protein	-
AABA19_RS02570 (TKY121806_05030)	comA/nlmT	502849..503496 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
AABA19_RS02575 (TKY121806_05040)	comA/nlmT	503512..504525 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=106416 AABA19_RS02550 WP_001219120.1 499130..499867(+) (comE/blpR) [Streptococcus pneumoniae strain Sep4]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=106416 AABA19_RS02550 WP_001219120.1 499130..499867(+) (comE/blpR) [Streptococcus pneumoniae strain Sep4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363