Detailed information NTG0106348

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AABA07_RS04730
• Genome accession: NZ_AP028608
• Coordinates: 932350..933054 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain Sep3
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 927350..938054

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA07_RS04710 (TKY120829_09430)	coaC	927639..928190 (-)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-
AABA07_RS04715 (TKY120829_09440)	coaB	928202..928891 (-)	690	WP_000699531.1	phosphopantothenate--cysteine ligase	-
AABA07_RS04720 (TKY120829_09450)	-	929121..930791 (+)	1671	WP_000845295.1	formate--tetrahydrofolate ligase	-
AABA07_RS04725 (TKY120829_09460)	mutY	931120..932295 (+)	1176	WP_000886144.1	A/G-specific adenine glycosylase	-
AABA07_RS04730 (TKY120829_09470)	micA	932350..933054 (+)	705	WP_000722076.1	response regulator YycF	Regulator
AABA07_RS04735 (TKY120829_09480)	micB	933047..934396 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AABA07_RS04740 (TKY120829_09490)	vicX	934398..935207 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
AABA07_RS04745 (TKY120829_09500)	-	935298..935540 (+)	243	WP_338172919.1	DUF6290 family protein	-
AABA07_RS04750 (TKY120829_09510)	-	935542..935796 (+)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AABA07_RS04755 (TKY120829_09520)	-	935843..936586 (+)	744	WP_000731133.1	potassium channel family protein	-
AABA07_RS04760 (TKY120829_09530)	-	936875..937861 (-)	987	WP_000204731.1	L-lactate dehydrogenase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=106348 AABA07_RS04730 WP_000722076.1 932350..933054(+) (micA) [Streptococcus pneumoniae strain Sep3]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=106348 AABA07_RS04730 WP_000722076.1 932350..933054(+) (micA) [Streptococcus pneumoniae strain Sep3]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38