Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   AAA982_RS05725 Genome accession   NZ_AP028601
Coordinates   1122923..1123627 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain PF1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1117923..1128627
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA982_RS05695 (TKY113292_11160) - 1118128..1119114 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  AAA982_RS05700 (TKY113292_11170) - 1119391..1120134 (-) 744 Protein_1126 ion channel -
  AAA982_RS05705 (TKY113292_11180) - 1120181..1120435 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  AAA982_RS05710 (TKY113292_11190) - 1120437..1120679 (-) 243 WP_000208080.1 DUF6290 family protein -
  AAA982_RS05715 (TKY113292_11200) vicX 1120770..1121579 (-) 810 WP_050103757.1 MBL fold metallo-hydrolase Regulator
  AAA982_RS05720 (TKY113292_11210) micB 1121581..1122930 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  AAA982_RS05725 (TKY113292_11220) micA 1122923..1123627 (-) 705 WP_000722076.1 response regulator YycF Regulator
  AAA982_RS05730 (TKY113292_11230) mutY 1123683..1124858 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  AAA982_RS05735 (TKY113292_11240) - 1125187..1126857 (-) 1671 WP_338168240.1 formate--tetrahydrofolate ligase -
  AAA982_RS05740 (TKY113292_11250) coaB 1127087..1127776 (+) 690 WP_338168241.1 phosphopantothenate--cysteine ligase -
  AAA982_RS05745 (TKY113292_11260) coaC 1127788..1128339 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=105810 AAA982_RS05725 WP_000722076.1 1122923..1123627(-) (micA) [Streptococcus pneumoniae strain PF1]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=105810 AAA982_RS05725 WP_000722076.1 1122923..1123627(-) (micA) [Streptococcus pneumoniae strain PF1]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTATGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment