Detailed information NTG1043498

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: ACD269_RS06090
• Genome accession: NZ_CP168260
• Coordinates: 1185771..1186619 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705310.1
• Uniprot ID: C1C7P4
• Organism: Streptococcus pneumoniae strain FC2
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1180771..1191619

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD269_RS06070 (ACD269_06070)	-	1181125..1181484 (-)	360	WP_001237219.1	YbaN family protein	-
ACD269_RS06075 (ACD269_06075)	topA	1181590..1183677 (-)	2088	WP_000179641.1	type I DNA topoisomerase	-
ACD269_RS06080 (ACD269_06080)	-	1183844..1184887 (-)	1044	WP_015898771.1	DUF389 domain-containing protein	-
ACD269_RS06085 (ACD269_06085)	-	1185465..1185587 (+)	123	WP_001814242.1	hypothetical protein	-
ACD269_RS06090 (ACD269_06090)	dprA/cilB/dalA	1185771..1186619 (-)	849	WP_000705310.1	DNA-processing protein DprA	Machinery gene
ACD269_RS06095 (ACD269_06095)	-	1186715..1187404 (-)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
ACD269_RS06100 (ACD269_06100)	-	1187416..1188294 (-)	879	WP_000837609.1	DMT family transporter	-
ACD269_RS06105 (ACD269_06105)	licA	1188284..1189153 (-)	870	WP_000411199.1	choline kinase LicA	-
ACD269_RS06110 (ACD269_06110)	-	1189170..1190192 (-)	1023	WP_000609894.1	ribitol-5-phosphate dehydrogenase	-
ACD269_RS06115 (ACD269_06115)	-	1190197..1190904 (-)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31080.76 Da
• Isoelectric Point: 5.4047

>NTDB_id=1043498 ACD269_RS06090 WP_000705310.1 1185771..1186619(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain FC2]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGMAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=1043498 ACD269_RS06090 WP_000705310.1 1185771..1186619(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain FC2]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTATTGGGTGATATTGCAGATATCTCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTATGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: C1C7P4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.645	100	0.996
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.227	100	0.982
dprA/cilB/dalA	Streptococcus mitis SK321	97.518	100	0.975
dprA	Streptococcus mutans UA159	62.857	99.291	0.624
dprA	Lactococcus lactis subsp. cremoris KW2	55.357	99.291	0.55
dprA	Staphylococcus aureus N315	37.456	100	0.376