Detailed information NTG1037919

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ACB363_RS04780
• Genome accession: NZ_CP167021
• Coordinates: 934338..935174 (-)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain Isolate 5
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 929338..940174

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB363_RS04760 (ACB363_04760)	-	929556..930548 (-)	993	WP_021299266.1	D-lactate dehydrogenase	-
ACB363_RS04765 (ACB363_04765)	-	930563..931129 (-)	567	Protein_892	PTS sugar transporter subunit IIC	-
ACB363_RS04770 (ACB363_04770)	-	931142..932026 (+)	885	Protein_893	LysR family transcriptional regulator	-
ACB363_RS04775 (ACB363_04775)	topA	932102..934231 (-)	2130	WP_011528644.1	type I DNA topoisomerase	-
ACB363_RS04780 (ACB363_04780)	dprA	934338..935174 (-)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
ACB363_RS04785 (ACB363_04785)	-	935239..936030 (-)	792	WP_371400258.1	ribonuclease HII	-
ACB363_RS04790 (ACB363_04790)	ylqF	936020..936868 (-)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
ACB363_RS04795 (ACB363_04795)	-	937087..937527 (+)	441	WP_011017769.1	DUF1836 domain-containing protein	-
ACB363_RS04800 (ACB363_04800)	-	937524..938174 (+)	651	WP_002984629.1	hemolysin III family protein	-
ACB363_RS04805 (ACB363_04805)	-	938291..939202 (+)	912	WP_011528643.1	diacylglycerol kinase family protein	-
ACB363_RS04810 (ACB363_04810)	-	939252..939686 (-)	435	WP_021299262.1	hypothetical protein	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=1037919 ACB363_RS04780 WP_011017772.1 934338..935174(-) (dprA) [Streptococcus pyogenes strain Isolate 5]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1037919 ACB363_RS04780 WP_011017772.1 934338..935174(-) (dprA) [Streptococcus pyogenes strain Isolate 5]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367