Detailed information NTG1037756

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ACB344_RS04980
• Genome accession: NZ_CP167018
• Coordinates: 969865..970701 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain Isolate 8
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 964865..975701

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB344_RS04950 (ACB344_04950)	-	965353..965787 (+)	435	WP_021299262.1	hypothetical protein	-
ACB344_RS04955 (ACB344_04955)	-	965837..966748 (-)	912	WP_011528643.1	diacylglycerol kinase family protein	-
ACB344_RS04960 (ACB344_04960)	-	966865..967515 (-)	651	WP_002984629.1	hemolysin III family protein	-
ACB344_RS04965 (ACB344_04965)	-	967512..967952 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
ACB344_RS04970 (ACB344_04970)	ylqF	968171..969019 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
ACB344_RS04975 (ACB344_04975)	-	969009..969800 (+)	792	WP_011017771.1	ribonuclease HII	-
ACB344_RS04980 (ACB344_04980)	dprA	969865..970701 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
ACB344_RS04985 (ACB344_04985)	topA	970808..972937 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
ACB344_RS04990 (ACB344_04990)	-	973013..973897 (-)	885	Protein_936	LysR family transcriptional regulator	-
ACB344_RS04995 (ACB344_04995)	-	973910..974476 (+)	567	Protein_937	PTS sugar transporter subunit IIC	-
ACB344_RS05000 (ACB344_05000)	-	974491..975483 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=1037756 ACB344_RS04980 WP_011017772.1 969865..970701(+) (dprA) [Streptococcus pyogenes strain Isolate 8]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=1037756 ACB344_RS04980 WP_011017772.1 969865..970701(+) (dprA) [Streptococcus pyogenes strain Isolate 8]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367