Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   ACB354_RS07740 Genome accession   NZ_CP167004
Coordinates   1469914..1470624 (-) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 28     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1464914..1475624
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB354_RS07725 (ACB354_07730) rnc 1466632..1467324 (-) 693 WP_002985639.1 ribonuclease III -
  ACB354_RS07730 (ACB354_07735) vicX 1467756..1468565 (-) 810 WP_011184291.1 MBL fold metallo-hydrolase Regulator
  ACB354_RS07735 (ACB354_07740) vicK 1468569..1469921 (-) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACB354_RS07740 (ACB354_07745) vicR 1469914..1470624 (-) 711 WP_002985645.1 response regulator YycF Regulator
  ACB354_RS07745 (ACB354_07750) - 1470786..1471820 (-) 1035 WP_011184290.1 DUF3114 domain-containing protein -
  ACB354_RS07750 (ACB354_07755) - 1471876..1473123 (-) 1248 WP_011184289.1 AMP-binding protein -
  ACB354_RS07755 (ACB354_07760) - 1473080..1474228 (-) 1149 WP_011889082.1 acetyl-CoA C-acyltransferase -
  ACB354_RS07760 (ACB354_07765) - 1474197..1474766 (-) 570 WP_011889083.1 hypothetical protein -
  ACB354_RS07765 (ACB354_07770) - 1474901..1475614 (-) 714 WP_313769765.1 MIP/aquaporin family protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=1037053 ACB354_RS07740 WP_002985645.1 1469914..1470624(-) (vicR) [Streptococcus pyogenes strain Isolate 28]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=1037053 ACB354_RS07740 WP_002985645.1 1469914..1470624(-) (vicR) [Streptococcus pyogenes strain Isolate 28]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACTCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment