Detailed information NTG1024256

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: DQN31_RS08700
• Genome accession: NZ_LS483421
• Coordinates: 1724804..1727359 (-)
• Length: 851 a.a.
• NCBI ID: WP_014407950.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC10877
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1719804..1732359

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQN31_RS08665 (NCTC10877_01710)	-	1721038..1721211 (+)	174	WP_000694577.1	hypothetical protein	-
DQN31_RS09090 (NCTC10877_01711)	-	1721217..1721390 (+)	174	WP_014407944.1	hypothetical protein	-
DQN31_RS08670 (NCTC10877_01712)	-	1721392..1721901 (+)	510	WP_014407945.1	hypothetical protein	-
DQN31_RS08675 (NCTC10877_01713)	-	1721975..1722463 (+)	489	WP_014407946.1	hypothetical protein	-
DQN31_RS08685 (NCTC10877_01714)	-	1722869..1723231 (+)	363	WP_014407947.1	DUF1492 domain-containing protein	-
DQN31_RS08690 (NCTC10877_01715)	-	1723206..1723589 (+)	384	WP_014407948.1	ArpU family phage packaging/lysis transcriptional regulator	-
DQN31_RS08695 (NCTC10877_01716)	-	1723790..1724407 (+)	618	WP_014411913.1	hypothetical protein	-
DQN31_RS08700 (NCTC10877_01717)	hexA	1724804..1727359 (-)	2556	WP_014407950.1	DNA mismatch repair protein MutS	Machinery gene
DQN31_RS09350 (NCTC10877_01718)	-	1727346..1727552 (-)	207	WP_010922774.1	YlbF family regulator	-
DQN31_RS08710 (NCTC10877_01719)	argR	1727695..1728132 (-)	438	WP_002982171.1	arginine repressor	-
DQN31_RS08715 (NCTC10877_01720)	argS	1728423..1730114 (+)	1692	WP_014407951.1	arginine--tRNA ligase	-
DQN31_RS08720 (NCTC10877_01721)	-	1730202..1730510 (+)	309	WP_014407952.1	bacteriocin immunity protein	-
DQN31_RS08725 (NCTC10877_01722)	-	1730537..1731409 (-)	873	WP_002982164.1	YitT family protein	-
DQN31_RS08730 (NCTC10877_01723)	-	1731452..1732330 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95416.97 Da
• Isoelectric Point: 5.0620

>NTDB_id=1024256 DQN31_RS08700 WP_014407950.1 1724804..1727359(-) (hexA) [Streptococcus pyogenes strain NCTC10877]
MAKTNISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=1024256 DQN31_RS08700 WP_014407950.1 1724804..1727359(-) (hexA) [Streptococcus pyogenes strain NCTC10877]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAAATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGGAGTCTGTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTAACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGCGGCATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGATATTATTTCCACGTTACGACTTCAAATCTTAGCTTAGTGCCTGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAACGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGTGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.445	100	0.714
mutS	Pseudomonas stutzeri strain ATCC 17587	37.383	100	0.376