Detailed information NTG1020649

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: AB1F71_RS00375
• Genome accession: NZ_CP160386
• Coordinates: 61438..62352 (+)
• Length: 304 a.a.
• NCBI ID: WP_002263400.1
• Uniprot ID: Q8DWI6
• Organism: Streptococcus mutans strain UA159 ykuR deletion
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 56438..67352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB1F71_RS00345 (AB1F71_00345)	-	56836..56930 (+)	95	Protein_47	phosphoribosylaminoimidazole carboxylase	-
AB1F71_RS00350 (AB1F71_00350)	-	56932..57195 (+)	264	WP_002263395.1	hypothetical protein	-
AB1F71_RS00355 (AB1F71_00355)	-	57215..57440 (+)	226	Protein_49	phosphoribosylaminoimidazole carboxylase	-
AB1F71_RS00360 (AB1F71_00360)	-	57446..58741 (+)	1296	WP_002263397.1	hypothetical protein	-
AB1F71_RS00365 (AB1F71_00365)	purB	59051..60349 (+)	1299	WP_002263398.1	adenylosuccinate lyase	-
AB1F71_RS00370 (AB1F71_00370)	-	60369..61055 (+)	687	WP_002263399.1	DNA alkylation repair protein	-
AB1F71_RS00375 (AB1F71_00375)	comR	61438..62352 (+)	915	WP_002263400.1	helix-turn-helix domain-containing protein	Regulator
AB1F71_RS00380 (AB1F71_00380)	-	62886..64727 (-)	1842	WP_002263401.1	carbohydrate-binding domain-containing protein	-
AB1F71_RS00385 (AB1F71_00385)	ruvB	65063..66058 (+)	996	WP_002263402.1	Holliday junction branch migration DNA helicase RuvB	-
AB1F71_RS00390 (AB1F71_00390)	-	66096..66521 (+)	426	WP_002263403.1	low molecular weight protein-tyrosine-phosphatase	-
AB1F71_RS00395 (AB1F71_00395)	-	66586..66969 (+)	384	WP_011074470.1	membrane protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35247.28 Da
• Isoelectric Point: 4.8341

>NTDB_id=1020649 AB1F71_RS00375 WP_002263400.1 61438..62352(+) (comR) [Streptococcus mutans strain UA159 ykuR deletion]
MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELK
YLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVND
LILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMD
RTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT

Nucleotide

• Length: 915 bp

>NTDB_id=1020649 AB1F71_RS00375 WP_002263400.1 61438..62352(+) (comR) [Streptococcus mutans strain UA159 ykuR deletion]
ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAAGCTGTCTGCCTTGATGA
ATCTCAATTGTCAACACGGCAGTTGACCAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTG
CAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAG
TATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAG
TCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTG
ACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGAT
TTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAA
TCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGA
ATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGAT
AGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGC
GGAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGA
AAGAATGGCAAAAAGATTCTCAGAACGGGACATAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (9-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• PDB: 7N10
• PDB: 7N1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	100	100	1
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.778	94.737	0.5
comR	Streptococcus pyogenes MGAS315	47.157	98.355	0.464
comR	Streptococcus pyogenes MGAS8232	46.358	99.342	0.461
comR	Streptococcus suis P1/7	43.813	98.355	0.431
comR	Streptococcus suis 05ZYH33	43.813	98.355	0.431
comR	Streptococcus suis D9	37	98.684	0.365