Detailed information NTG1018103

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQL28_RS07260
• Genome accession: NZ_LS483334
• Coordinates: 1433214..1435367 (+)
• Length: 717 a.a.
• NCBI ID: WP_111676662.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12050
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1428214..1440367

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL28_RS07215	stcA	1428644..1428913 (+)	270	WP_020833327.1	quorum-sensing system protein StcA	-
DQL28_RS07220 (NCTC12050_01436)	-	1429261..1429659 (-)	399	WP_168690190.1	histidine kinase	-
DQL28_RS09685	-	1429752..1430822 (-)	1071	Protein_1351	hypothetical protein	-
DQL28_RS07230 (NCTC12050_01440)	-	1431073..1431474 (-)	402	WP_047235194.1	hypothetical protein	-
DQL28_RS07235 (NCTC12050_01441)	-	1431668..1431949 (-)	282	WP_111676660.1	hypothetical protein	-
DQL28_RS07240 (NCTC12050_01442)	-	1431999..1432193 (-)	195	WP_002990768.1	hypothetical protein	-
DQL28_RS07250 (NCTC12050_01443)	-	1432487..1432687 (-)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQL28_RS07255 (NCTC12050_01444)	-	1432700..1432927 (-)	228	WP_042361549.1	Blp family class II bacteriocin	-
DQL28_RS07260 (NCTC12050_01445)	comA/nlmT	1433214..1435367 (+)	2154	WP_111676662.1	peptide cleavage/export ABC transporter	Regulator
DQL28_RS07265 (NCTC12050_01446)	-	1435378..1436742 (+)	1365	WP_111676664.1	bacteriocin secretion accessory protein	-
DQL28_RS07270 (NCTC12050_01447)	-	1436819..1436944 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQL28_RS07275 (NCTC12050_01448)	-	1437092..1438426 (-)	1335	WP_080147975.1	sensor histidine kinase	-
DQL28_RS07280 (NCTC12050_01449)	comE/blpR	1438427..1439176 (-)	750	WP_030126108.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80678.66 Da
• Isoelectric Point: 7.0107

>NTDB_id=1018103 DQL28_RS07260 WP_111676662.1 1433214..1435367(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC12050]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLSIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILYLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HADIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=1018103 DQL28_RS07260 WP_111676662.1 1433214..1435367(+) (comA/nlmT) [Streptococcus pyogenes strain NCTC12050]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCAGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTATCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGCAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.448	99.721	0.722
comA	Streptococcus mitis NCTC 12261	67.227	99.582	0.669
comA	Streptococcus mitis SK321	66.807	99.582	0.665
comA	Streptococcus pneumoniae Rx1	66.807	99.582	0.665
comA	Streptococcus pneumoniae D39	66.807	99.582	0.665
comA	Streptococcus pneumoniae R6	66.807	99.582	0.665
comA	Streptococcus pneumoniae TIGR4	66.527	99.582	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	65.877	100	0.66