Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | CD-RCd/- |
Location | 1147503..1147718 | Replicon | chromosome |
Accession | NZ_CP016318 | ||
Organism | Clostridioides difficile strain 630 delta erm |
Toxin (Protein)
Gene name | CD0977.1 | Uniprot ID | Q18AH6 |
Locus tag | CDIF630erm_RS20630 | Protein ID | WP_011861054.1 |
Coordinates | 1147503..1147646 (+) | Length | 48 a.a. |
Antitoxin (RNA)
Gene name | RCd11 | ||
Locus tag | - | ||
Coordinates | 1147568..1147718 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDIF630erm_RS05680 | 1142690..1142872 | + | 183 | WP_011861045.1 | hypothetical protein | - |
CDIF630erm_RS05685 | 1142907..1143137 | + | 231 | WP_011861046.1 | hemolysin XhlA family protein | - |
CDIF630erm_RS05690 | 1143157..1143417 | + | 261 | WP_011861047.1 | phage holin family protein | - |
CDIF630erm_RS05695 | 1143414..1144229 | + | 816 | WP_011861048.1 | N-acetylmuramoyl-L-alanine amidase | - |
CDIF630erm_RS05700 | 1144246..1144542 | + | 297 | WP_011861049.1 | hypothetical protein | - |
CDIF630erm_RS05705 | 1145055..1145651 | + | 597 | WP_011861051.1 | hypothetical protein | - |
CDIF630erm_RS05710 | 1145669..1146100 | + | 432 | WP_011861052.1 | protein-export chaperone SecB | - |
CDIF630erm_RS05715 | 1146102..1146806 | + | 705 | WP_011861053.1 | hypothetical protein | - |
CDIF630erm_RS05720 | 1147054..1147242 | - | 189 | WP_009898401.1 | hypothetical protein | - |
CDIF630erm_RS20630 | 1147503..1147646 | + | 144 | WP_011861054.1 | hypothetical protein | Toxin |
- | 1147568..1147718 | - | 151 | NuclAT_0 | - | Antitoxin |
- | 1147572..1147718 | - | 147 | NuclAT_3 | - | - |
CDIF630erm_RS05730 | 1148260..1148541 | + | 282 | WP_009898394.1 | BlaI/MecI/CopY family transcriptional regulator | - |
CDIF630erm_RS05735 | 1148581..1148967 | + | 387 | WP_011861055.1 | BlaI/MecI/CopY family transcriptional regulator | - |
CDIF630erm_RS05740 | 1149153..1149677 | + | 525 | Protein_1009 | 4Fe-4S dicluster domain-containing protein | - |
CDIF630erm_RS05745 | 1150061..1151299 | + | 1239 | WP_011861056.1 | hypothetical protein | - |
CDIF630erm_RS05750 | 1151328..1152215 | + | 888 | WP_011861057.1 | decaprenyl-phosphate phosphoribosyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1076912..1148967 | 72055 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5337.27 Da Isoelectric Point: 10.5719
>T64403 WP_011861054.1 NZ_CP016318:1147503-1147646 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKLNKKQH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKLNKKQH
Download Length: 144 bp
>T64403 NZ_CP016318:1147503-1147646 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA
Antitoxin
Download Length: 151 bp
>AT64403 NZ_CP016318:c1147718-1147568 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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