Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1147503..1147718 Replicon chromosome
Accession NZ_CP016318
Organism Clostridioides difficile strain 630 delta erm

Toxin (Protein)


Gene name CD0977.1 Uniprot ID Q18AH6
Locus tag CDIF630erm_RS20630 Protein ID WP_011861054.1
Coordinates 1147503..1147646 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name RCd11
Locus tag -
Coordinates 1147568..1147718 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630erm_RS05680 1142690..1142872 + 183 WP_011861045.1 hypothetical protein -
CDIF630erm_RS05685 1142907..1143137 + 231 WP_011861046.1 hemolysin XhlA family protein -
CDIF630erm_RS05690 1143157..1143417 + 261 WP_011861047.1 phage holin family protein -
CDIF630erm_RS05695 1143414..1144229 + 816 WP_011861048.1 N-acetylmuramoyl-L-alanine amidase -
CDIF630erm_RS05700 1144246..1144542 + 297 WP_011861049.1 hypothetical protein -
CDIF630erm_RS05705 1145055..1145651 + 597 WP_011861051.1 hypothetical protein -
CDIF630erm_RS05710 1145669..1146100 + 432 WP_011861052.1 protein-export chaperone SecB -
CDIF630erm_RS05715 1146102..1146806 + 705 WP_011861053.1 hypothetical protein -
CDIF630erm_RS05720 1147054..1147242 - 189 WP_009898401.1 hypothetical protein -
CDIF630erm_RS20630 1147503..1147646 + 144 WP_011861054.1 hypothetical protein Toxin
- 1147568..1147718 - 151 NuclAT_0 - Antitoxin
- 1147572..1147718 - 147 NuclAT_3 - -
CDIF630erm_RS05730 1148260..1148541 + 282 WP_009898394.1 BlaI/MecI/CopY family transcriptional regulator -
CDIF630erm_RS05735 1148581..1148967 + 387 WP_011861055.1 BlaI/MecI/CopY family transcriptional regulator -
CDIF630erm_RS05740 1149153..1149677 + 525 Protein_1009 4Fe-4S dicluster domain-containing protein -
CDIF630erm_RS05745 1150061..1151299 + 1239 WP_011861056.1 hypothetical protein -
CDIF630erm_RS05750 1151328..1152215 + 888 WP_011861057.1 decaprenyl-phosphate phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1076912..1148967 72055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5337.27 Da        Isoelectric Point: 10.5719

>T64403 WP_011861054.1 NZ_CP016318:1147503-1147646 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKLNKKQH

Download         Length: 144 bp

>T64403 NZ_CP016318:1147503-1147646 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA

Antitoxin


Download         Length: 151 bp

>AT64403 NZ_CP016318:c1147718-1147568 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q18AH6

Antitoxin

Download structure file

References