Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1129404..1129618 Replicon chromosome
Accession NZ_CP016318
Organism Clostridioides difficile strain 630 delta erm

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDIF630erm_RS20625 Protein ID WP_003429855.1
Coordinates 1129404..1129565 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1129485..1129618 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF630erm_RS05565 1124743..1124976 + 234 WP_009896624.1 hypothetical protein -
CDIF630erm_RS05570 1124986..1125387 + 402 WP_009888836.1 hypothetical protein -
CDIF630erm_RS05575 1125381..1125728 + 348 WP_003429844.1 hypothetical protein -
CDIF630erm_RS05580 1125728..1126153 + 426 WP_011861030.1 HK97 gp10 family phage protein -
CDIF630erm_RS05585 1126146..1126583 + 438 WP_009901504.1 hypothetical protein -
CDIF630erm_RS20620 1126576..1126752 + 177 WP_011861031.1 hypothetical protein -
CDIF630erm_RS05595 1126754..1128064 + 1311 WP_011861032.1 phage tail sheath family protein -
CDIF630erm_RS05600 1128081..1128551 + 471 WP_003429851.1 phage tail tube protein -
CDIF630erm_RS05605 1128623..1129063 + 441 WP_003429853.1 phage portal protein -
CDIF630erm_RS20625 1129404..1129565 + 162 WP_003429855.1 hypothetical protein Toxin
- 1129485..1129618 - 134 NuclAT_5 - Antitoxin
- 1129485..1129618 - 134 NuclAT_7 - Antitoxin
- 1129963..1130068 - 106 NuclAT_11 - -
- 1129963..1130068 - 106 NuclAT_13 - -
CDIF630erm_RS05620 1131229..1131789 + 561 WP_011861034.1 lipoprotein -
CDIF630erm_RS05625 1131833..1132402 + 570 WP_011861035.1 zinc-ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1076912..1148967 72055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T64399 WP_003429855.1 NZ_CP016318:1129404-1129565 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T64399 NZ_CP016318:1129404-1129565 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin


Download         Length: 134 bp

>AT64399 NZ_CP016318:c1129618-1129485 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References