Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/- |
| Location | 910591..911873 | Replicon | chromosome |
| Accession | NC_009442 | ||
| Organism | Streptococcus suis 05ZYH33 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | SSU05_0936 | Protein ID | YP_001198302.1 |
| Coordinates | 910591..911367 (-) | Length | 259 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | SSU05_0937 | Protein ID | YP_001198303.1 |
| Coordinates | 911367..911873 (-) | Length | 169 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSU05_0933 | 905632..905946 | - | 315 | YP_001198299.1 | hypothetical protein | - |
| SSU05_0934 | 907006..908550 | - | 1545 | YP_001198300.1 | DNA helicase | - |
| SSU05_0935 | 908507..910594 | - | 2088 | YP_001198301.1 | hypothetical protein | - |
| SSU05_0936 | 910591..911367 | - | 777 | YP_001198302.1 | Signal recognition particle GTPase | Toxin |
| SSU05_0937 | 911367..911873 | - | 507 | YP_001198303.1 | transcriptional regulator | Antitoxin |
| SSU05_0938 | 911913..912266 | - | 354 | YP_001198304.1 | ATPases with chaperone activity, ATP-binding subunit | - |
| SSU05_0939 | 912253..912642 | - | 390 | YP_001198305.1 | methyl-accepting chemotaxis protein | - |
| SSU05_0940 | 912639..912866 | - | 228 | YP_001198306.1 | hypothetical protein | - |
| SSU05_0941 | 912920..913996 | - | 1077 | YP_001198307.1 | DNA primase (type) | - |
| SSU05_0942 | 914035..914673 | - | 639 | YP_001198308.1 | hypothetical protein | - |
| SSU05_0943 | 916074..916673 | - | 600 | YP_001198309.1 | DNA-binding response regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 259 a.a. Molecular weight: 29171.98 Da Isoelectric Point: 5.2489
>T6280 YP_001198302.1 NC_009442:c911367-910591 [Streptococcus suis 05ZYH33]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK
Download Length: 777 bp
>T6280 NC_009442:c911367-910591 [Streptococcus suis 05ZYH33]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA
Antitoxin
Download Length: 169 a.a. Molecular weight: 19458.12 Da Isoelectric Point: 4.7704
>AT6280 YP_001198303.1 NC_009442:c911873-911367 [Streptococcus suis 05ZYH33]
MKANMRRSLSMIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPV
EDYHLTLKVEVIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLD
MVHHRVVA
MKANMRRSLSMIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPV
EDYHLTLKVEVIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLD
MVHHRVVA
Download Length: 507 bp
>AT6280 NC_009442:c911873-911367 [Streptococcus suis 05ZYH33]
ATGAAAGCAAATATGAGGAGGTCTTTATCTATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACA
GCCAGAATTTGCGAAAATGGTCGGGATTTCACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTG
AACTCATCGACCGTATTTGTCAGAAATTTAACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTC
GAAGATTACCATCTGACTTTAAAAGTAGAAGTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCA
AGATAGTCAGGATATTGCTTTTGATGATGAATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATA
CGAAAATTTACCTTGTCGATACTTTCGATGAAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGAC
ATGGTGCATCATCGGGTGGTGGCTTAA
ATGAAAGCAAATATGAGGAGGTCTTTATCTATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACA
GCCAGAATTTGCGAAAATGGTCGGGATTTCACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTG
AACTCATCGACCGTATTTGTCAGAAATTTAACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTC
GAAGATTACCATCTGACTTTAAAAGTAGAAGTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCA
AGATAGTCAGGATATTGCTTTTGATGATGAATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATA
CGAAAATTTACCTTGTCGATACTTTCGATGAAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGAC
ATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6037 | Enterococcus faecium |
95.816 |
93.359 |
0.895 |
| T6282 | Streptococcus pneumoniae R6 |
68.924 |
99.209 |
0.684 |
| T10019 | Streptococcus pneumoniae TIGR4 |
68.526 |
99.209 |
0.68 |
| T6080 | Streptococcus pneumoniae gamPNI0373 |
68.127 |
99.209 |
0.676 |
| T6024 | Streptococcus pyogenes |
43.75 |
86.822 |
0.38 |
| T6079 | Streptococcus pyogenes |
43.75 |
86.822 |
0.38 |
| T6092 | Staphylococcus aureus |
43.75 |
86.822 |
0.38 |
| T6104 | Enterococcus faecalis |
44.231 |
80.62 |
0.357 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6037 | Enterococcus faecium |
99.405 |
100 |
0.994 |
| AT6282 | Streptococcus pneumoniae R6 |
81.013 |
100 |
0.81 |
| AT10019 | Streptococcus pneumoniae TIGR4 |
81.013 |
100 |
0.81 |
| AT6080 | Streptococcus pneumoniae gamPNI0373 |
81.013 |
100 |
0.81 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Xinyue Yao et al. (2015) The chromosomal SezAT toxin-antitoxin system promotes the maintenance of the SsPI-1 pathogenicity island in epidemic Streptococcus suis. Molecular Microbiology 98(2):243-57. [PubMed:26138696]