Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) pezAT/-
Location 78500..79776 Replicon ICE
Accession HE963029
Organism Enterococcus faecium

Toxin (Protein)


Gene name pezA Uniprot ID -
Locus tag Locus_75 Protein ID CCJ27800.1
Coordinates 79006..79776 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag Locus_74 Protein ID CCJ27799.1
Coordinates 78500..79006 (+) Length 169 a.a.

Genomic Context

Locus_69Locus_70Locus_71Locus_72Locus_73Locus_74Locus_75Locus_76Locus_77Locus_78Locus_68
Location: 75699..76337 (639 bp)
Type: Others
Protein ID: CCJ27794.1
Location: 76377..77453 (1077 bp)
Type: Others
Protein ID: CCJ27795.1
Location: 77507..77734 (228 bp)
Type: Others
Protein ID: CCJ27796.1
Location: 77731..78120 (390 bp)
Type: Others
Protein ID: CCJ27797.1
Location: 78170..78460 (291 bp)
Type: Others
Protein ID: CCJ27798.1
Location: 78500..79006 (507 bp)
Type: Antitoxin
Protein ID: CCJ27799.1
Location: 79006..79776 (771 bp)
Type: Toxin
Protein ID: CCJ27800.1
Location: 79808..82315 (2508 bp)
Type: Others
Protein ID: CCJ27801.1
Location: 82636..82995 (360 bp)
Type: Others
Protein ID: CCJ27802.1
Location: 83005..83370 (366 bp)
Type: Others
Protein ID: CCJ27803.1
Location: 74246..75503 (1258 bp)
Type: Others
Protein ID: Protein_68
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Locus_6874246..75503-1258Protein_68transposase, ISL3 family (pseudogene)-
Locus_6975699..76337+639CCJ27794.1putative uncharacterized protein-
Locus_7076377..77453+1077CCJ27795.1putative DNA primase-
Locus_7177507..77734+228CCJ27796.1putative uncharacterized protein-
Locus_7277731..78120+390CCJ27797.1putative uncharacterized protein-
Locus_7378170..78460+291CCJ27798.1putative uncharacterized protein-
Locus_7478500..79006+507CCJ27799.1putative antidote epsilon protein, zeta toxin regulatorAntitoxin
Locus_7579006..79776+771CCJ27800.1putative zeta-toxin/signal recognition particleToxin
Locus_7679808..82315+2508CCJ27801.1putative uncharacterized protein-
Locus_7782636..82995+360CCJ27802.1putative uncharacterized protein-
Locus_7883005..83370+366CCJ27803.1putative mobilisation protein, MobC family-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--74246..753551109


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-70)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29084.03 Da        Isoelectric Point: 7.4269

>T6037 CCJ27800.1 HE963029:79006-79776 [Enterococcus faecium]
MRLEEFSEAGFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMG
RRVNSYLMNYLRKINN

Download         Length: 771 bp

>T6037 HE963029:79006-79776 [Enterococcus faecium]
ATGAGGTTGGAAGAATTCAGTGAGGCTGGGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATAGATCCGACTCAGGCCAGAGCAACCCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGGA
AGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAATTGA

Antitoxin


Download         Length: 169 a.a.        Molecular weight: 19449.11 Da        Isoelectric Point: 4.6595

>AT6037 CCJ27799.1 HE963029:78500-79006 [Enterococcus faecium]
MKANMRRSLSMIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPV
EDYQLTLKVEVIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLD
MVHHRVVA

Download         Length: 507 bp

>AT6037 HE963029:78500-79006 [Enterococcus faecium]
ATGAAAGCAAATATGAGGAGGTCTTTATCTATGATTGGAGACAATATCAAGTCACTACGCCGAACACATGATTTAACACA
ACCAGAATTTGCGAAAATGGTTGGTATTTCACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTG
AACTCATCGACCGTATTTGTCAGAAATTTAACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTT
GAAGATTACCAACTGACTTTAAAAGTAGAAGTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCA
GGATAGTCAAGATATTGCTTTTGATGATGAATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACA
CAAAAATTTACCTTGTCGATACTTTCGATGAAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGAC
ATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T6280Streptococcus suis 05ZYH33

95.816

93.359

0.895

T6282Streptococcus pneumoniae R6

68.526

99.209

0.68

T6080Streptococcus pneumoniae gamPNI0373

68.127

99.209

0.676

T10019Streptococcus pneumoniae TIGR4

68.127

99.209

0.676

T6092Staphylococcus aureus

40.167

93.359

0.375

T6079Streptococcus pyogenes

40.167

93.359

0.375

T6104Enterococcus faecalis

40.167

93.359

0.375

T6024Streptococcus pyogenes

40.167

93.359

0.375
Showing 1 to 8 of 8 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT6280Streptococcus suis 05ZYH33

99.405

100

0.994

AT6080Streptococcus pneumoniae gamPNI0373

81.013

100

0.81

AT6282Streptococcus pneumoniae R6

81.013

100

0.81

AT10019Streptococcus pneumoniae TIGR4

81.013

100

0.81
Showing 1 to 4 of 4 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Eva K Bjørkeng et al. (2013) ICESluvan, a 94-kilobase mosaic integrative conjugative element conferring interspecies transfer of VanB-type glycopeptide resistance, a novel bacitracin resistance locus, and a toxin-antitoxin stabilization system. Journal of Bacteriology 195(23):5381-90. [PubMed:24078615] experimental


experimental experimental literature