Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/- |
| Location | 78500..79776 | Replicon | ICE |
| Accession | HE963029 | ||
| Organism | Enterococcus faecium | ||
Toxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | Locus_75 | Protein ID | CCJ27800.1 |
| Coordinates | 79006..79776 (+) | Length | 257 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | Locus_74 | Protein ID | CCJ27799.1 |
| Coordinates | 78500..79006 (+) | Length | 169 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Locus_68 | 74246..75503 | - | 1258 | Protein_68 | transposase, ISL3 family (pseudogene) | - |
| Locus_69 | 75699..76337 | + | 639 | CCJ27794.1 | putative uncharacterized protein | - |
| Locus_70 | 76377..77453 | + | 1077 | CCJ27795.1 | putative DNA primase | - |
| Locus_71 | 77507..77734 | + | 228 | CCJ27796.1 | putative uncharacterized protein | - |
| Locus_72 | 77731..78120 | + | 390 | CCJ27797.1 | putative uncharacterized protein | - |
| Locus_73 | 78170..78460 | + | 291 | CCJ27798.1 | putative uncharacterized protein | - |
| Locus_74 | 78500..79006 | + | 507 | CCJ27799.1 | putative antidote epsilon protein, zeta toxin regulator | Antitoxin |
| Locus_75 | 79006..79776 | + | 771 | CCJ27800.1 | putative zeta-toxin/signal recognition particle | Toxin |
| Locus_76 | 79808..82315 | + | 2508 | CCJ27801.1 | putative uncharacterized protein | - |
| Locus_77 | 82636..82995 | + | 360 | CCJ27802.1 | putative uncharacterized protein | - |
| Locus_78 | 83005..83370 | + | 366 | CCJ27803.1 | putative mobilisation protein, MobC family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 74246..75355 | 1109 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 257 a.a. Molecular weight: 29084.03 Da Isoelectric Point: 7.4269
>T6037 CCJ27800.1 HE963029:79006-79776 [Enterococcus faecium]
MRLEEFSEAGFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMG
RRVNSYLMNYLRKINN
MRLEEFSEAGFQKALQRTIRALTRGKTIPGQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMG
RRVNSYLMNYLRKINN
Download Length: 771 bp
>T6037 HE963029:79006-79776 [Enterococcus faecium]
ATGAGGTTGGAAGAATTCAGTGAGGCTGGGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATAGATCCGACTCAGGCCAGAGCAACCCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGGA
AGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAATTGA
ATGAGGTTGGAAGAATTCAGTGAGGCTGGGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATAGATCCGACTCAGGCCAGAGCAACCCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGGA
AGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAATTGA
Antitoxin
Download Length: 169 a.a. Molecular weight: 19449.11 Da Isoelectric Point: 4.6595
>AT6037 CCJ27799.1 HE963029:78500-79006 [Enterococcus faecium]
MKANMRRSLSMIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPV
EDYQLTLKVEVIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLD
MVHHRVVA
MKANMRRSLSMIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPV
EDYQLTLKVEVIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLD
MVHHRVVA
Download Length: 507 bp
>AT6037 HE963029:78500-79006 [Enterococcus faecium]
ATGAAAGCAAATATGAGGAGGTCTTTATCTATGATTGGAGACAATATCAAGTCACTACGCCGAACACATGATTTAACACA
ACCAGAATTTGCGAAAATGGTTGGTATTTCACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTG
AACTCATCGACCGTATTTGTCAGAAATTTAACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTT
GAAGATTACCAACTGACTTTAAAAGTAGAAGTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCA
GGATAGTCAAGATATTGCTTTTGATGATGAATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACA
CAAAAATTTACCTTGTCGATACTTTCGATGAAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGAC
ATGGTGCATCATCGGGTGGTGGCTTAA
ATGAAAGCAAATATGAGGAGGTCTTTATCTATGATTGGAGACAATATCAAGTCACTACGCCGAACACATGATTTAACACA
ACCAGAATTTGCGAAAATGGTTGGTATTTCACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTG
AACTCATCGACCGTATTTGTCAGAAATTTAACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTT
GAAGATTACCAACTGACTTTAAAAGTAGAAGTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCA
GGATAGTCAAGATATTGCTTTTGATGATGAATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACA
CAAAAATTTACCTTGTCGATACTTTCGATGAAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGAC
ATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6280 | Streptococcus suis 05ZYH33 |
95.816 |
93.359 |
0.895 |
| T6282 | Streptococcus pneumoniae R6 |
68.526 |
99.209 |
0.68 |
| T6080 | Streptococcus pneumoniae gamPNI0373 |
68.127 |
99.209 |
0.676 |
| T10019 | Streptococcus pneumoniae TIGR4 |
68.127 |
99.209 |
0.676 |
| T6092 | Staphylococcus aureus |
40.167 |
93.359 |
0.375 |
| T6079 | Streptococcus pyogenes |
40.167 |
93.359 |
0.375 |
| T6104 | Enterococcus faecalis |
40.167 |
93.359 |
0.375 |
| T6024 | Streptococcus pyogenes |
40.167 |
93.359 |
0.375 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6280 | Streptococcus suis 05ZYH33 |
99.405 |
100 |
0.994 |
| AT6080 | Streptococcus pneumoniae gamPNI0373 |
81.013 |
100 |
0.81 |
| AT6282 | Streptococcus pneumoniae R6 |
81.013 |
100 |
0.81 |
| AT10019 | Streptococcus pneumoniae TIGR4 |
81.013 |
100 |
0.81 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Eva K Bjørkeng et al. (2013) ICESluvan, a 94-kilobase mosaic integrative conjugative element conferring interspecies transfer of VanB-type glycopeptide resistance, a novel bacitracin resistance locus, and a toxin-antitoxin stabilization system. Journal of Bacteriology 195(23):5381-90. [PubMed:24078615]