Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/- |
| Location | 3461..4598 | Replicon | plasmid pW9-2 |
| Accession | NG_041566 | ||
| Organism | Enterococcus faecalis | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | pJHW9-2_006 | Protein ID | YP_009090346.1 |
| Coordinates | 3735..4598 (+) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | - |
| Locus tag | pJHW9-2_005 | Protein ID | YP_009090345.1 |
| Coordinates | 3461..3733 (+) | Length | 91 a.a. |
Regulator (Protein)
| Gene name | omega | Uniprot ID | - |
| Locus tag | pJHW9-2_004 | Protein ID | YP_009090344.1 |
| Coordinates | 3229..3444 (+) | Length | 72 a.a. |
Genomic Context
Location: 76..813 (738 bp)
Type: Others
Protein ID: YP_009090341.1
Type: Others
Protein ID: YP_009090341.1
Location: 2241..3137 (897 bp)
Type: Others
Protein ID: YP_009090343.1
Type: Others
Protein ID: YP_009090343.1
Location: 3229..3444 (216 bp)
Type: Regulator
Protein ID: YP_009090344.1
Type: Regulator
Protein ID: YP_009090344.1
Location: 3461..3733 (273 bp)
Type: Antitoxin
Protein ID: YP_009090345.1
Type: Antitoxin
Protein ID: YP_009090345.1
Location: 3735..4598 (864 bp)
Type: Toxin
Protein ID: YP_009090346.1
Type: Toxin
Protein ID: YP_009090346.1
Location: 5038..5355 (318 bp)
Type: Others
Protein ID: YP_009090347.1
Type: Others
Protein ID: YP_009090347.1
Location: 5878..6384 (507 bp)
Type: Others
Protein ID: YP_009090348.1
Type: Others
Protein ID: YP_009090348.1
Location: 6759..7931 (1173 bp)
Type: Others
Protein ID: YP_009090349.1
Type: Others
Protein ID: YP_009090349.1
Location: 1345..1767 (423 bp)
Type: Others
Protein ID: YP_009090342.1
Type: Others
Protein ID: YP_009090342.1
Location: 8364..9413 (1050 bp)
Type: Others
Protein ID: YP_009090350.1
Type: Others
Protein ID: YP_009090350.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| pJHW9-2_001 | 76..813 | + | 738 | YP_009090341.1 | ErmB | - |
| pJHW9-2_002 | 1345..1767 | - | 423 | YP_009090342.1 | hyprothetical protein | - |
| pJHW9-2_003 | 2241..3137 | + | 897 | YP_009090343.1 | CobQ/CobB/MinD/ParA nucleotide binding domain protein | - |
| pJHW9-2_004 | 3229..3444 | + | 216 | YP_009090344.1 | omega transcriptional repressor | Regulator |
| pJHW9-2_005 | 3461..3733 | + | 273 | YP_009090345.1 | epsilon antitoxin | Antitoxin |
| pJHW9-2_006 | 3735..4598 | + | 864 | YP_009090346.1 | zeta toxin | Toxin |
| pJHW9-2_007 | 5038..5355 | + | 318 | YP_009090347.1 | ssDNA binding protein | - |
| pJHW9-2_008 | 5878..6384 | + | 507 | YP_009090348.1 | hypothetical protein | - |
| pJHW9-2_009 | 6759..7931 | + | 1173 | YP_009090349.1 | transposase | - |
| pJHW9-2_010 | 8364..9413 | - | 1050 | YP_009090350.1 | rRNA methylase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | erm(B) / cfr | - | 1..25761 | 25761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32370.87 Da Isoelectric Point: 6.6610
>T6104 YP_009090346.1 NG_041566:3735-4598 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T6104 NG_041566:3735-4598 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT6104 YP_009090345.1 NG_041566:3461-3733 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT6104 NG_041566:3461-3733 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
Regulator
Download Length: 72 a.a. Molecular weight: 7956.31 Da Isoelectric Point: 10.3185
>RE6104 YP_009090344.1 NG_041566:3229-3444 [Enterococcus faecalis]
VIVGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKNGGNVKEVMDKALEEYIRKYLPDKL
VIVGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKNGGNVKEVMDKALEEYIRKYLPDKL
Download Length: 216 bp
>RE6104 NG_041566:3229-3444 [Enterococcus faecalis]
GTGATTGTGGGAAATTTAGGCGCACAAAAAGCAAAACGAAATGATACACCAATCAGTGCAAAAAAAGATATAATGGGAGA
TAAGACGGTTCGTGTTCGTGCTGACTTGCACCATATCATAAAAATCGAAACAGCAAAGAATGGCGGAAACGTAAAAGAAG
TTATGGATAAAGCCTTAGAAGAATATATTCGGAAATATTTACCTGACAAACTTTAA
GTGATTGTGGGAAATTTAGGCGCACAAAAAGCAAAACGAAATGATACACCAATCAGTGCAAAAAAAGATATAATGGGAGA
TAAGACGGTTCGTGTTCGTGCTGACTTGCACCATATCATAAAAATCGAAACAGCAAAGAATGGCGGAAACGTAAAAGAAG
TTATGGATAAAGCCTTAGAAGAATATATTCGGAAATATTTACCTGACAAACTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6024 | Streptococcus pyogenes | 97.561 | 100 | 0.976 |
| T6079 | Streptococcus pyogenes | 97.561 | 100 | 0.976 |
| T6092 | Staphylococcus aureus | 97.561 | 100 | 0.976 |
| T6037 | Enterococcus faecium | 40.167 | 93.359 | 0.375 |
| T6080 | Streptococcus pneumoniae gamPNI0373 | 43.318 | 85.771 | 0.372 |
| T6282 | Streptococcus pneumoniae R6 | 42.593 | 85.375 | 0.364 |
| T10019 | Streptococcus pneumoniae TIGR4 | 42.13 | 85.375 | 0.36 |
| T6280 | Streptococcus suis 05ZYH33 | 44.231 | 80.62 | 0.357 |
Showing 1 to 8 of 8 rows
Multiple sequence alignment
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6079 | Streptococcus pyogenes | 100 | 100 | 1 |
| AT6092 | Staphylococcus aureus | 100 | 100 | 1 |
| AT6024 | Streptococcus pyogenes | 100 | 100 | 1 |
Showing 1 to 3 of 3 rows
Multiple sequence alignment
References
(1) Yang Liu et al. (2013) Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment. Antimicrobial Agents And Chemotherapy 57(1):42-8. [PubMed:23070165]