Detailed information of TA system TA053081

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1126848..1127063
• Replicon: chromosome
• Accession: NZ_CP010905
• Organism: Clostridioides difficile 630

Toxin (Protein)

• Gene name: CD0977.1
• Uniprot ID: Q18AH6
• Locus tag: CDIF630_RS20465
• Protein ID: WP_011861054.1
• Coordinates: 1126848..1126991 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RCd11
Locus tag	-
Coordinates	1126913..1127063 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF630_RS05565	1122035..1122217	+	183	WP_011861045.1	hypothetical protein	-
CDIF630_RS05570	1122252..1122482	+	231	WP_011861046.1	hemolysin XhlA family protein	-
CDIF630_RS05575	1122502..1122762	+	261	WP_011861047.1	phage holin family protein	-
CDIF630_RS05580	1122759..1123574	+	816	WP_011861048.1	N-acetylmuramoyl-L-alanine amidase	-
CDIF630_RS05585	1123591..1123887	+	297	WP_011861049.1	hypothetical protein	-
CDIF630_RS05590	1124433..1124996	+	564	WP_021371073.1	hypothetical protein	-
CDIF630_RS05595	1125014..1125445	+	432	WP_011861052.1	protein-export chaperone SecB	-
CDIF630_RS05600	1125447..1126151	+	705	WP_011861732.1	hypothetical protein	-
CDIF630_RS05605	1126399..1126587	-	189	WP_009898401.1	hypothetical protein	-
CDIF630_RS20465	1126848..1126991	+	144	WP_011861054.1	hypothetical protein	Toxin
-	1126913..1127063	-	151	NuclAT_0	-	Antitoxin
-	1126917..1127063	-	147	NuclAT_3	-	-
CDIF630_RS05615	1127605..1127886	+	282	WP_009898394.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF630_RS05620	1127926..1128312	+	387	WP_011861055.1	BlaI/MecI/CopY family transcriptional regulator	-
CDIF630_RS05625	1128498..1129022	+	525	Protein_987	4Fe-4S dicluster domain-containing protein	-
CDIF630_RS05630	1129406..1130644	+	1239	WP_011861056.1	hypothetical protein	-
CDIF630_RS05635	1130673..1131560	+	888	WP_011861057.1	decaprenyl-phosphate phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_009089 Clostridium difficile 630 Prophage TA010080, TA010082, TA010083, TA010173 1078053..1143688 0.003	inside	Prophage	-	-	1056256..1128312	72056

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5337.27 Da
• Isoelectric Point: 10.5719

>T53081 WP_011861054.1 NZ_CP010905:1126848-1126991 [Clostridioides difficile 630]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKLNKKQH

Nucleotide

• Length: 144 bp

>T53081 NZ_CP010905:1126848-1126991 [Clostridioides difficile 630]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTGAAAATCAAGCTTAATAAAAAACAACATTAA

Antitoxin

Nucleotide

• Length: 151 bp

>AT53081 NZ_CP010905:c1127063-1126913 [Clostridioides difficile 630]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTT
GTTTTTTATTAAGCTTGATTTTCACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG

Structures

Toxin

• AlphaFold DB: Q18AH6

Antitoxin