Detailed information of TA system TA053077

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1108748..1108962
• Replicon: chromosome
• Accession: NZ_CP010905
• Organism: Clostridioides difficile 630

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF630_RS20460
• Protein ID: WP_003429855.1
• Coordinates: 1108748..1108909 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1108829..1108962 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF630_RS05450	1104087..1104320	+	234	WP_009896624.1	hypothetical protein	-
CDIF630_RS05455	1104330..1104731	+	402	WP_009888836.1	hypothetical protein	-
CDIF630_RS05460	1104725..1105072	+	348	WP_003429844.1	hypothetical protein	-
CDIF630_RS05465	1105072..1105497	+	426	WP_011861030.1	HK97 gp10 family phage protein	-
CDIF630_RS05470	1105490..1105927	+	438	WP_009901504.1	hypothetical protein	-
CDIF630_RS20455	1105920..1106096	+	177	WP_011861031.1	hypothetical protein	-
CDIF630_RS05480	1106098..1107408	+	1311	WP_011861032.1	phage tail sheath family protein	-
CDIF630_RS05485	1107425..1107895	+	471	WP_003429851.1	phage tail tube protein	-
CDIF630_RS05490	1107967..1108407	+	441	WP_003429853.1	phage portal protein	-
CDIF630_RS20460	1108748..1108909	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1108829..1108962	-	134	NuclAT_5	-	Antitoxin
-	1108829..1108962	-	134	NuclAT_7	-	Antitoxin
-	1109307..1109412	-	106	NuclAT_11	-	-
-	1109307..1109412	-	106	NuclAT_13	-	-
CDIF630_RS05505	1110573..1111133	+	561	WP_011861034.1	lipoprotein	-
CDIF630_RS05510	1111177..1111747	+	571	Protein_964	zinc-ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_009089 Clostridium difficile 630 Prophage TA010080, TA010082, TA010083, TA010173 1078053..1143688 0.003	inside	Prophage	-	-	1056256..1128312	72056

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T53077 WP_003429855.1 NZ_CP010905:1108748-1108909 [Clostridioides difficile 630]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T53077 NZ_CP010905:1108748-1108909 [Clostridioides difficile 630]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT53077 NZ_CP010905:c1108962-1108829 [Clostridioides difficile 630]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin