47613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2006630..2006967 Replicon chromosome
Accession NZ_CP008816
Organism Enterococcus faecalis ATCC 29212

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag DR75_RS10545 Protein ID WP_002381035.1
Coordinates 2006630..2006773 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2006705..2006967 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR75_RS10530 (DR75_1952) 2002729..2003358 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
DR75_RS10540 (DR75_1953) 2004051..2005667 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
DR75_RS15750 2005997..2006140 + 144 WP_002392818.1 putative holin-like toxin -
DR75_RS15755 2006259..2006399 + 141 WP_073340360.1 putative holin-like toxin -
DR75_RS10545 (DR75_1954) 2006630..2006773 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2006705..2006967 - 263 - - Antitoxin
DR75_RS10550 (DR75_1955) 2006968..2011659 - 4692 WP_010784674.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 1970908..2015454 44546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T47613 WP_002381035.1 NZ_CP008816:2006630-2006773 [Enterococcus faecalis ATCC 29212]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T47613 NZ_CP008816:2006630-2006773 [Enterococcus faecalis ATCC 29212]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 263 bp

>AT47613 NZ_CP008816:c2006967-2006705 [Enterococcus faecalis ATCC 29212]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References