Detailed information of TA system TA143545

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 383351..383688
• Replicon: chromosome
• Accession: NZ_CP046111
• Organism: Enterococcus faecalis strain 111540047-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: GKQ56_RS01960
• Protein ID: WP_002381035.1
• Coordinates: 383545..383688 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	383351..383613 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ56_RS01955	378659..383350	+	4692	WP_010784674.1	WxL domain-containing protein	-
-	383351..383613	+	263	NuclAT_10	-	Antitoxin
-	383352..383401	-	50	NuclAT_13	-	-
GKQ56_RS01960	383545..383688	-	144	WP_002381035.1	putative holin-like toxin	Toxin
-	383788..383986	+	199	NuclAT_6	-	-
GKQ56_RS01965	383919..384059	-	141	WP_073340360.1	putative holin-like toxin	-
-	384061..384204	+	144	NuclAT_12	-	-
-	384061..384245	+	185	NuclAT_8	-	-
GKQ56_RS01970	384178..384321	-	144	WP_002392818.1	putative holin-like toxin	-
GKQ56_RS01975	384651..386267	-	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
GKQ56_RS01980	386960..387589	+	630	WP_002354763.1	lytic polysaccharide monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP008816 Enterococcus faecalis ATCC 29212 Integrative and Conjugative Element TA010090, TA047601, TA047604, TA047607, TA047610, TA047613, TA047616 1970908..2015454 0.002	inside	Integrative and Conjugative Element	-	-	374757..415223	40466

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T143545 WP_002381035.1 NZ_CP046111:c383688-383545 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T143545 NZ_CP061188:88649-89047 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 263 bp

>AT143545 NZ_CP046111:383351-383613 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin