281841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2836359..2836930 Replicon chromosome
Accession NZ_CP124923
Organism Enterococcus faecalis strain EfsC11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QLQ48_RS13835 Protein ID WP_002354774.1
Coordinates 2836359..2836700 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QLQ48_RS13840 Protein ID WP_002354773.1
Coordinates 2836700..2836930 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ48_RS13830 (2832374) 2832374..2835988 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ48_RS13835 (2836359) 2836359..2836700 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ48_RS13840 (2836700) 2836700..2836930 - 231 WP_002354773.1 hypothetical protein Antitoxin
QLQ48_RS13845 (2837105) 2837105..2837320 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ48_RS13850 (2837459) 2837459..2838451 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ48_RS13855 (2838715) 2838715..2839344 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ48_RS13860 (2840037) 2840037..2841653 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2806896..2851440 44544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T281841 WP_002354774.1 NZ_CP124923:c2836700-2836359 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT281841 WP_002354773.1 NZ_CP124923:c2836930-2836700 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References