281848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2842318..2842759 Replicon chromosome
Accession NZ_CP124923
Organism Enterococcus faecalis strain EfsC11

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag QLQ48_RS13875 Protein ID WP_002381035.1
Coordinates 2842616..2842759 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2842318..2842516 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ48_RS13850 (2837459) 2837459..2838451 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ48_RS13855 (2838715) 2838715..2839344 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ48_RS13860 (2840037) 2840037..2841653 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
QLQ48_RS13865 (2841983) 2841983..2842126 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
- (2842059) 2842059..2842243 - 185 NuclAT_8 - -
- (2842100) 2842100..2842243 - 144 NuclAT_12 - -
QLQ48_RS13870 (2842245) 2842245..2842385 + 141 WP_073340360.1 putative holin-like toxin -
- (2842318) 2842318..2842516 - 199 NuclAT_6 - Antitoxin
QLQ48_RS13875 (2842616) 2842616..2842759 + 144 WP_002381035.1 putative holin-like toxin Toxin
- (2842903) 2842903..2842952 + 50 NuclAT_13 - -
- (2842691) 2842691..2842953 - 263 NuclAT_10 - -
QLQ48_RS13880 (2842954) 2842954..2847645 - 4692 WP_282897468.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2806896..2851440 44544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T281848 WP_002381035.1 NZ_CP124923:2842616-2842759 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT281848 NZ_CP124923:c2842516-2842318 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References