143548

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 383545..383986 Replicon chromosome
Accession NZ_CP046111
Organism Enterococcus faecalis strain 111540047-1

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag GKQ56_RS01960 Protein ID WP_002381035.1
Coordinates 383545..383688 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 383788..383986 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ56_RS01955 378659..383350 + 4692 WP_010784674.1 WxL domain-containing protein -
- 383351..383613 + 263 NuclAT_10 - -
- 383352..383401 - 50 NuclAT_13 - -
GKQ56_RS01960 383545..383688 - 144 WP_002381035.1 putative holin-like toxin Toxin
- 383788..383986 + 199 NuclAT_6 - Antitoxin
GKQ56_RS01965 383919..384059 - 141 WP_073340360.1 putative holin-like toxin -
- 384061..384204 + 144 NuclAT_12 - -
- 384061..384245 + 185 NuclAT_8 - -
GKQ56_RS01970 384178..384321 - 144 WP_002392818.1 putative holin-like toxin -
GKQ56_RS01975 384651..386267 - 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
GKQ56_RS01980 386960..387589 + 630 WP_002354763.1 lytic polysaccharide monooxygenase -
GKQ56_RS01985 387853..388845 - 993 WP_142426550.1 biotin--[acetyl-CoA-carboxylase] ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 374757..415223 40466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T143548 WP_002381035.1 NZ_CP046111:c383688-383545 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T143548 NZ_CP061188:138437-138853 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 199 bp

>AT143548 NZ_CP046111:383788-383986 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References