143560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 389374..389945 Replicon chromosome
Accession NZ_CP046111
Organism Enterococcus faecalis strain 111540047-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GKQ56_RS02000 Protein ID WP_002354774.1
Coordinates 389604..389945 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag GKQ56_RS01995 Protein ID WP_002354773.1
Coordinates 389374..389604 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ56_RS01975 384651..386267 - 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
GKQ56_RS01980 386960..387589 + 630 WP_002354763.1 lytic polysaccharide monooxygenase -
GKQ56_RS01985 387853..388845 - 993 WP_142426550.1 biotin--[acetyl-CoA-carboxylase] ligase -
GKQ56_RS01990 388984..389199 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
GKQ56_RS01995 389374..389604 + 231 WP_002354773.1 hypothetical protein Antitoxin
GKQ56_RS02000 389604..389945 + 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GKQ56_RS02005 390316..393930 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 374757..415223 40466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T143560 WP_002354774.1 NZ_CP046111:389604-389945 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T143560 NZ_CP061204:330658-330795 [Stenotrophomonas sp. 169]
ATGAAGCGTGCTATTGCCCTGATGCTGTTGTCCATGTTCTCGGTCGCCATGCTGGCCGGCTGCAACACCGTTGCCGGCGC
CGGCAAGGATGTGCAGGGTGCAGGCGAGAAGGTGGAAGACGCCGCCCGCAAGAACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT143560 WP_002354773.1 NZ_CP046111:389374-389604 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT143560 NZ_CP061204:330439-330591 [Stenotrophomonas sp. 169]
ATGAAGCGAATCATTTCCGTACTGTTGTTTGCGCTGTGCACCGCAGGTTCGCTGACCGCCTGCAATACCGTTGCCGGTGC
CGGCAAGGACATGCAGAGCGCTGGCGATGCTGTCCATGACACCGCGCAGGACTGCAAAAACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References