Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1129404..1129618 Replicon chromosome
Accession NZ_LN614756
Organism Clostridioides difficile strain 630Derm

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CD630DERM_RS20890 Protein ID WP_003429855.1
Coordinates 1129404..1129565 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1129485..1129618 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD630DERM_RS05450 1124743..1124976 + 234 WP_009896624.1 hypothetical protein -
CD630DERM_RS05455 1124986..1125387 + 402 WP_009888836.1 hypothetical protein -
CD630DERM_RS05460 1125381..1125728 + 348 WP_003429844.1 hypothetical protein -
CD630DERM_RS05465 1125728..1126153 + 426 WP_011861030.1 HK97 gp10 family phage protein -
CD630DERM_RS05470 1126146..1126583 + 438 WP_009901504.1 hypothetical protein -
CD630DERM_RS20885 1126576..1126752 + 177 WP_011861031.1 hypothetical protein -
CD630DERM_RS05480 1126754..1128064 + 1311 WP_011861032.1 phage tail sheath family protein -
CD630DERM_RS05485 1128081..1128551 + 471 WP_003429851.1 phage tail tube protein -
CD630DERM_RS05490 1128623..1129063 + 441 WP_003429853.1 phage portal protein -
CD630DERM_RS20890 1129404..1129565 + 162 WP_003429855.1 hypothetical protein Toxin
- 1129485..1129618 - 134 NuclAT_5 - Antitoxin
- 1129485..1129618 - 134 NuclAT_7 - Antitoxin
- 1129963..1130068 - 106 NuclAT_11 - -
- 1129963..1130068 - 106 NuclAT_13 - -
CD630DERM_RS05500 1131229..1131789 + 561 WP_011861034.1 lipoprotein -
CD630DERM_RS05505 1131833..1132402 + 570 WP_011861035.1 zinc-ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1076912..1148967 72055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T285464 WP_003429855.1 NZ_LN614756:1129404-1129565 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 134 bp

>AT285464 NZ_LN614756:c1129618-1129485 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References