Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   ABD408_RS02275 Genome accession   NZ_CP155735
Coordinates   432973..433683 (+) Length   236 a.a.
NCBI ID   WP_023612167.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 4958/15     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 427973..438683
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABD408_RS02255 (ABD408_02240) - 428825..428974 (+) 150 WP_002990686.1 hypothetical protein -
  ABD408_RS02260 (ABD408_02245) - 429369..430517 (+) 1149 WP_023612171.1 acetyl-CoA C-acyltransferase -
  ABD408_RS02265 (ABD408_02250) - 430474..431721 (+) 1248 WP_023612155.1 AMP-binding protein -
  ABD408_RS02270 (ABD408_02255) - 431777..432811 (+) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  ABD408_RS02275 (ABD408_02260) vicR 432973..433683 (+) 711 WP_023612167.1 response regulator YycF Regulator
  ABD408_RS02280 (ABD408_02265) vicK 433676..435028 (+) 1353 WP_023078748.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ABD408_RS02285 (ABD408_02270) vicX 435032..435841 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  ABD408_RS02290 (ABD408_02275) rnc 436272..436964 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27112.00 Da        Isoelectric Point: 4.9038

>NTDB_id=998904 ABD408_RS02275 WP_023612167.1 432973..433683(+) (vicR) [Streptococcus pyogenes strain 4958/15]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEERPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=998904 ABD408_RS02275 WP_023612167.1 432973..433683(+) (vicR) [Streptococcus pyogenes strain 4958/15]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAGGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGGCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment