Detailed information NTG0998879

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ABD408_RS00270
• Genome accession: NZ_CP155735
• Coordinates: 46872..47783 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 4958/15
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 41872..52783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD408_RS00250 (ABD408_00245)	purE	42458..42949 (+)	492	WP_023612097.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ABD408_RS00255 (ABD408_00250)	purK	42936..44009 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ABD408_RS00260 (ABD408_00255)	-	44011..45429 (+)	1419	WP_023612101.1	hypothetical protein	-
ABD408_RS00265 (ABD408_00260)	purB	45449..46741 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
ABD408_RS00270 (ABD408_00265)	comR	46872..47783 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
ABD408_RS00275	comS	47863..47961 (+)	99	WP_206733287.1	quorum-sensing system DWW-type pheromone	Regulator
ABD408_RS00280 (ABD408_00270)	ruvB	48008..49006 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ABD408_RS00285 (ABD408_00275)	-	49144..49581 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ABD408_RS00290 (ABD408_00280)	-	49604..50005 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ABD408_RS00295 (ABD408_00285)	-	50002..51777 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=998879 ABD408_RS00270 WP_002986681.1 46872..47783(+) (comR) [Streptococcus pyogenes strain 4958/15]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=998879 ABD408_RS00270 WP_002986681.1 46872..47783(+) (comR) [Streptococcus pyogenes strain 4958/15]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462