Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ABC806_RS04575 Genome accession   NZ_CP155539
Coordinates   871079..871816 (+) Length   245 a.a.
NCBI ID   WP_000782668.1    Uniprot ID   Q97Q68
Organism   Streptococcus pneumoniae TIGR4     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 866079..876816
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC806_RS04555 (ABC806_04550) - 866276..867379 (+) 1104 WP_000225907.1 glycosyltransferase -
  ABC806_RS04560 (ABC806_04555) - 867381..868367 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  ABC806_RS04565 (ABC806_04560) - 868383..869816 (+) 1434 WP_000565078.1 O-antigen polysaccharide polymerase Wzy family protein -
  ABC806_RS04570 (ABC806_04565) - 869845..870879 (+) 1035 WP_000461505.1 hypothetical protein -
  ABC806_RS04575 (ABC806_04570) mecA 871079..871816 (+) 738 WP_000782668.1 adaptor protein MecA Regulator
  ABC806_RS04580 (ABC806_04575) - 871967..873253 (+) 1287 WP_000216382.1 homoserine dehydrogenase -
  ABC806_RS04585 (ABC806_04580) thrB 873255..874124 (+) 870 WP_000692438.1 homoserine kinase -
  ABC806_RS04590 (ABC806_04585) - 874200..874391 (+) 192 WP_001808580.1 hypothetical protein -
  ABC806_RS04595 (ABC806_04590) msrB 874420..875358 (+) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28391.20 Da        Isoelectric Point: 4.0199

>NTDB_id=997578 ABC806_RS04575 WP_000782668.1 871079..871816(+) (mecA) [Streptococcus pneumoniae TIGR4]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEVKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=997578 ABC806_RS04575 WP_000782668.1 871079..871816(+) (mecA) [Streptococcus pneumoniae TIGR4]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGTCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q97Q68

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae TIGR4

100

100

1
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus thermophilus LMD-9

48.594

100

0.494
  mecA Streptococcus thermophilus LMG 18311

48.193

100

0.49
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment