Detailed information NTG0997169

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ABC814_RS06250
• Genome accession: NZ_CP155533
• Coordinates: 1219573..1220277 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain Spn1439-106
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1214573..1225277

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC814_RS06220 (ABC814_06215)	-	1214765..1215751 (+)	987	WP_000204725.1	L-lactate dehydrogenase	-
ABC814_RS06225 (ABC814_06220)	-	1216011..1216784 (-)	774	WP_000731135.1	ion transporter	-
ABC814_RS06230 (ABC814_06225)	-	1216831..1217085 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABC814_RS06235 (ABC814_06230)	relB	1217087..1217329 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
ABC814_RS06240 (ABC814_06235)	vicX	1217420..1218229 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
ABC814_RS06245 (ABC814_06240)	micB	1218231..1219580 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ABC814_RS06250 (ABC814_06245)	micA	1219573..1220277 (-)	705	WP_000722076.1	response regulator YycF	Regulator
ABC814_RS06255 (ABC814_06250)	mutY	1220332..1221507 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
ABC814_RS06260 (ABC814_06255)	-	1221604..1221729 (+)	126	WP_001818232.1	hypothetical protein	-
ABC814_RS06265 (ABC814_06260)	-	1221835..1223505 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
ABC814_RS06270 (ABC814_06265)	coaB	1223735..1224424 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
ABC814_RS06275 (ABC814_06270)	coaC	1224436..1224987 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=997169 ABC814_RS06250 WP_000722076.1 1219573..1220277(-) (micA) [Streptococcus pneumoniae strain Spn1439-106]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=997169 ABC814_RS06250 WP_000722076.1 1219573..1220277(-) (micA) [Streptococcus pneumoniae strain Spn1439-106]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTAGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38