Detailed information NTG0997153

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC814_RS02560
• Genome accession: NZ_CP155533
• Coordinates: 496594..497331 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219147.1
• Uniprot ID: B1IA60
• Organism: Streptococcus pneumoniae strain Spn1439-106
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 491594..502331

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC814_RS02525 (ABC814_02525)	-	492570..492764 (-)	195	WP_050267646.1	hypothetical protein	-
ABC814_RS02530 (ABC814_02530)	-	492926..493213 (-)	288	WP_000777760.1	hypothetical protein	-
ABC814_RS02535 (ABC814_02535)	-	493223..493633 (-)	411	WP_001278301.1	HIT family protein	-
ABC814_RS02540 (ABC814_02540)	pptA	493701..494432 (+)	732	WP_000889919.1	ABC transporter ATP-binding protein	Regulator
ABC814_RS02545 (ABC814_02545)	-	494429..495478 (+)	1050	WP_000653767.1	ABC transporter permease	-
ABC814_RS02550 (ABC814_02550)	-	495646..495975 (-)	330	WP_000132572.1	hypothetical protein	-
ABC814_RS02555 (ABC814_02555)	-	496251..496589 (+)	339	WP_000876676.1	LytTR family DNA-binding domain-containing protein	-
ABC814_RS02560 (ABC814_02560)	comE/blpR	496594..497331 (+)	738	WP_001219147.1	response regulator transcription factor	Regulator
ABC814_RS02565 (ABC814_02565)	-	497345..498685 (+)	1341	WP_001017622.1	sensor histidine kinase	-
ABC814_RS02570 (ABC814_02570)	blpC	498727..498882 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
ABC814_RS02575 (ABC814_02575)	-	498939..500300 (-)	1362	WP_001087624.1	bacteriocin secretion accessory protein	-
ABC814_RS02580 (ABC814_02580)	comA/nlmT	500311..501987 (-)	1677	WP_306293369.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28828.93 Da
• Isoelectric Point: 6.0454

>NTDB_id=997153 ABC814_RS02560 WP_001219147.1 496594..497331(+) (comE/blpR) [Streptococcus pneumoniae strain Spn1439-106]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSTEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=997153 ABC814_RS02560 WP_001219147.1 496594..497331(+) (comE/blpR) [Streptococcus pneumoniae strain Spn1439-106]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGACAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

3D structure

• AlphaFold DB: B1IA60

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363