Detailed information NTG0997123

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ABC810_RS07510
• Genome accession: NZ_CP155532
• Coordinates: 1478481..1479155 (-)
• Length: 224 a.a.
• NCBI ID: WP_000590619.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain SP264
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1479373..1480629	1478481..1479155	flank	218

Gene organization within MGE regions

Location: 1478481..1480629

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC810_RS07510 (ABC810_07500)	ciaR	1478481..1479155 (-)	675	WP_000590619.1	two-component system response regulator CiaR	Regulator
ABC810_RS07515 (ABC810_07505)	-	1479373..1480629 (+)	1257	WP_000436228.1	ISL3-like element IS1167A family transposase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25480.32 Da
• Isoelectric Point: 4.3283

>NTDB_id=997123 ABC810_RS07510 WP_000590619.1 1478481..1479155(-) (ciaR) [Streptococcus pneumoniae strain SP264]
MIKILLIEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=997123 ABC810_RS07510 WP_000590619.1 1478481..1479155(-) (ciaR) [Streptococcus pneumoniae strain SP264]
ATGATAAAAATCTTATTGATTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	99.554	100	0.996
ciaR	Streptococcus pneumoniae D39	99.554	100	0.996
ciaR	Streptococcus pneumoniae R6	99.554	100	0.996
ciaR	Streptococcus pneumoniae TIGR4	99.554	100	0.996
ciaR	Streptococcus mutans UA159	87.946	100	0.879
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.168	100	0.375
vicR	Streptococcus mutans UA159	35.193	100	0.366