Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ABC810_RS05610 Genome accession   NZ_CP155532
Coordinates   1091889..1092593 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain SP264     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1086889..1097593
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC810_RS05585 (ABC810_05575) coaC 1087179..1087730 (-) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -
  ABC810_RS05590 (ABC810_05580) coaB 1087742..1088431 (-) 690 WP_000699492.1 phosphopantothenate--cysteine ligase -
  ABC810_RS05595 (ABC810_05585) - 1088661..1090331 (+) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  ABC810_RS05600 (ABC810_05590) - 1090437..1090562 (-) 126 WP_001818232.1 hypothetical protein -
  ABC810_RS05605 (ABC810_05595) mutY 1090659..1091834 (+) 1176 WP_000886152.1 A/G-specific adenine glycosylase -
  ABC810_RS05610 (ABC810_05600) micA 1091889..1092593 (+) 705 WP_000722076.1 response regulator YycF Regulator
  ABC810_RS05615 (ABC810_05605) micB 1092586..1093935 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ABC810_RS05620 (ABC810_05610) vicX 1093937..1094746 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ABC810_RS05625 (ABC810_05615) relB 1094837..1095079 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ABC810_RS05630 (ABC810_05620) - 1095081..1095335 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ABC810_RS05635 (ABC810_05625) - 1095382..1096155 (+) 774 WP_000731139.1 ion channel -
  ABC810_RS05640 (ABC810_05630) - 1096403..1097389 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=997114 ABC810_RS05610 WP_000722076.1 1091889..1092593(+) (micA) [Streptococcus pneumoniae strain SP264]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=997114 ABC810_RS05610 WP_000722076.1 1091889..1092593(+) (micA) [Streptococcus pneumoniae strain SP264]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment