Detailed information NTG0994354

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AAYT22_RS02295
• Genome accession: NZ_CP154876
• Coordinates: 444633..445370 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain 20155336
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 439633..450370

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAYT22_RS02260 (AAYT22_02245)	-	440609..440803 (-)	195	WP_001808905.1	hypothetical protein	-
AAYT22_RS02265 (AAYT22_02250)	-	440965..441252 (-)	288	WP_000777760.1	hypothetical protein	-
AAYT22_RS02270 (AAYT22_02255)	-	441262..441672 (-)	411	WP_001278301.1	HIT family protein	-
AAYT22_RS02275 (AAYT22_02260)	pptA	441740..442471 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
AAYT22_RS02280 (AAYT22_02265)	-	442468..443517 (+)	1050	WP_000653771.1	ABC transporter permease	-
AAYT22_RS02285 (AAYT22_02270)	-	443685..444014 (-)	330	WP_000132572.1	hypothetical protein	-
AAYT22_RS02290 (AAYT22_02275)	-	444290..444628 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
AAYT22_RS02295 (AAYT22_02280)	comE/blpR	444633..445370 (+)	738	WP_001219122.1	response regulator transcription factor	Regulator
AAYT22_RS02300 (AAYT22_02285)	-	445384..446724 (+)	1341	WP_001017622.1	sensor histidine kinase	-
AAYT22_RS02305 (AAYT22_02290)	blpC	446766..446921 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
AAYT22_RS02310 (AAYT22_02295)	-	446978..448339 (-)	1362	WP_001069074.1	bacteriocin secretion accessory protein	-
AAYT22_RS02315 (AAYT22_02300)	comA/nlmT	448350..448997 (-)	648	WP_078064020.1	ATP-binding cassette domain-containing protein	Regulator
AAYT22_RS02320 (AAYT22_02305)	comA/nlmT	449013..450026 (-)	1014	WP_318528993.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=994354 AAYT22_RS02295 WP_001219122.1 444633..445370(+) (comE/blpR) [Streptococcus pneumoniae strain 20155336]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=994354 AAYT22_RS02295 WP_001219122.1 444633..445370(+) (comE/blpR) [Streptococcus pneumoniae strain 20155336]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38