Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EW025_RS07220 Genome accession   NZ_LR130238
Coordinates   1382363..1383004 (-) Length   213 a.a.
NCBI ID   WP_010922536.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain HKU419 isolate HKU419     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1377363..1388004
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW025_RS07195 comFA/cflA 1377449..1378774 (-) 1326 WP_010922534.1 DEAD/DEAH box helicase Machinery gene
  EW025_RS07200 - 1378830..1379462 (+) 633 WP_009880468.1 YigZ family protein -
  EW025_RS07205 cysK 1379590..1380531 (+) 942 WP_010922535.1 cysteine synthase A -
  EW025_RS07210 - 1380549..1380926 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  EW025_RS07215 - 1380926..1382326 (-) 1401 WP_011285657.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  EW025_RS07220 vraR 1382363..1383004 (-) 642 WP_010922536.1 response regulator transcription factor Regulator
  EW025_RS07225 - 1382997..1384001 (-) 1005 WP_002991890.1 sensor histidine kinase -
  EW025_RS07230 liaF 1383998..1384690 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  EW025_RS07235 pknB 1384813..1386711 (-) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  EW025_RS07240 - 1386708..1387448 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23693.40 Da        Isoelectric Point: 5.3506

>NTDB_id=994334 EW025_RS07220 WP_010922536.1 1382363..1383004(-) (vraR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=994334 EW025_RS07220 WP_010922536.1 1382363..1383004(-) (vraR) [Streptococcus pyogenes strain HKU419 isolate HKU419]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGGTGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment