Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   AAIS09_RS10580 Genome accession   NZ_CP154595
Coordinates   2073578..2074759 (+) Length   393 a.a.
NCBI ID   WP_000681598.1    Uniprot ID   A0A0B7M448
Organism   Streptococcus pneumoniae strain serotype 4     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2068578..2079759
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAIS09_RS10540 (AAIS09_10525) - 2069629..2070171 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  AAIS09_RS10555 (AAIS09_10540) comE 2070414..2071166 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  AAIS09_RS10560 (AAIS09_10545) comD/comD1 2071163..2072488 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  AAIS09_RS10565 (AAIS09_10550) comC/comC1 2072509..2072634 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  AAIS09_RS10575 (AAIS09_10560) rlmH 2072916..2073395 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AAIS09_RS10580 (AAIS09_10565) htrA 2073578..2074759 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  AAIS09_RS10585 (AAIS09_10570) spo0J 2074817..2075575 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41827.69 Da        Isoelectric Point: 6.8902

>NTDB_id=993731 AAIS09_RS10580 WP_000681598.1 2073578..2074759(+) (htrA) [Streptococcus pneumoniae strain serotype 4]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=993731 AAIS09_RS10580 WP_000681598.1 2073578..2074759(+) (htrA) [Streptococcus pneumoniae strain serotype 4]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTAACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M448

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.746

100

0.997
  htrA Streptococcus pneumoniae D39

99.746

100

0.997
  htrA Streptococcus pneumoniae R6

99.746

100

0.997
  htrA Streptococcus pneumoniae TIGR4

99.746

100

0.997
  htrA Streptococcus mitis NCTC 12261

97.455

100

0.975
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment