Detailed information NTG0993728

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: AAIS09_RS10555
• Genome accession: NZ_CP154595
• Coordinates: 2070414..2071166 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain serotype 4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2065414..2076166

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAIS09_RS10535 (AAIS09_10520)	-	2067847..2069450 (-)	1604	Protein_2036	YhgE/Pip family protein	-
AAIS09_RS10540 (AAIS09_10525)	-	2069629..2070171 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AAIS09_RS10555 (AAIS09_10540)	comE	2070414..2071166 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AAIS09_RS10560 (AAIS09_10545)	comD/comD1	2071163..2072488 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
AAIS09_RS10565 (AAIS09_10550)	comC/comC1	2072509..2072634 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
AAIS09_RS10575 (AAIS09_10560)	rlmH	2072916..2073395 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AAIS09_RS10580 (AAIS09_10565)	htrA	2073578..2074759 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
AAIS09_RS10585 (AAIS09_10570)	spo0J	2074817..2075575 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=993728 AAIS09_RS10555 WP_000866065.1 2070414..2071166(-) (comE) [Streptococcus pneumoniae strain serotype 4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=993728 AAIS09_RS10555 WP_000866065.1 2070414..2071166(-) (comE) [Streptococcus pneumoniae strain serotype 4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408