Detailed information NTG0993681

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AAIS09_RS05780
• Genome accession: NZ_CP154595
• Coordinates: 1147940..1148644 (-)
• Length: 234 a.a.
• NCBI ID: WP_061813425.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain serotype 4
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1142940..1153644

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAIS09_RS05750 (AAIS09_05735)	-	1143121..1144107 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
AAIS09_RS05755 (AAIS09_05740)	-	1144408..1145151 (-)	744	Protein_1137	potassium channel family protein	-
AAIS09_RS05760 (AAIS09_05745)	-	1145198..1145452 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
AAIS09_RS05765 (AAIS09_05750)	relB	1145454..1145696 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
AAIS09_RS05770 (AAIS09_05755)	vicX	1145787..1146596 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
AAIS09_RS05775 (AAIS09_05760)	micB	1146598..1147947 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AAIS09_RS05780 (AAIS09_05765)	micA	1147940..1148644 (-)	705	WP_061813425.1	response regulator YycF	Regulator
AAIS09_RS05785 (AAIS09_05770)	mutY	1148700..1149875 (-)	1176	WP_061813426.1	A/G-specific adenine glycosylase	-
AAIS09_RS05790 (AAIS09_05775)	-	1149972..1150097 (+)	126	WP_001818232.1	hypothetical protein	-
AAIS09_RS05795 (AAIS09_05780)	-	1150203..1151873 (-)	1671	WP_041171336.1	formate--tetrahydrofolate ligase	-
AAIS09_RS05800 (AAIS09_05785)	coaB	1152103..1152792 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
AAIS09_RS05805 (AAIS09_05790)	coaC	1152804..1153355 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26785.65 Da
• Isoelectric Point: 4.7799

>NTDB_id=993681 AAIS09_RS05780 WP_061813425.1 1147940..1148644(-) (micA) [Streptococcus pneumoniae strain serotype 4]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALVQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=993681 AAIS09_RS05780 WP_061813425.1 1147940..1148644(-) (micA) [Streptococcus pneumoniae strain serotype 4]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGTGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	99.573	100	0.996
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	43.723	98.718	0.432
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.043	98.291	0.423
scnR	Streptococcus mutans UA159	37.768	99.573	0.376