Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   AAIS09_RS02405 Genome accession   NZ_CP154595
Coordinates   467997..468689 (+) Length   230 a.a.
NCBI ID   WP_369917891.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain serotype 4     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 462997..473689
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAIS09_RS02375 (AAIS09_02370) - 464306..464593 (-) 288 WP_000777753.1 hypothetical protein -
  AAIS09_RS02380 (AAIS09_02375) - 464603..465013 (-) 411 WP_001278301.1 HIT family protein -
  AAIS09_RS02385 (AAIS09_02380) pptA 465081..465812 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  AAIS09_RS02390 (AAIS09_02385) - 465809..466858 (+) 1050 WP_061753515.1 ABC transporter permease -
  AAIS09_RS02395 (AAIS09_02390) - 467026..467355 (-) 330 WP_061753516.1 hypothetical protein -
  AAIS09_RS02400 (AAIS09_02395) - 467631..467969 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  AAIS09_RS02405 (AAIS09_02400) comE/blpR 467997..468689 (+) 693 WP_369917891.1 response regulator transcription factor Regulator
  AAIS09_RS02410 (AAIS09_02405) - 468703..470043 (+) 1341 WP_001017622.1 sensor histidine kinase -
  AAIS09_RS02415 (AAIS09_02410) blpC 470085..470240 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  AAIS09_RS02420 (AAIS09_02415) - 470297..471658 (-) 1362 WP_001069082.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26963.85 Da        Isoelectric Point: 6.4129

>NTDB_id=993668 AAIS09_RS02405 WP_369917891.1 467997..468689(+) (comE/blpR) [Streptococcus pneumoniae strain serotype 4]
METTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFM
PLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLETSPRPHRVILYTK
TDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEAINNLH

Nucleotide


Download         Length: 693 bp        

>NTDB_id=993668 AAIS09_RS02405 WP_369917891.1 467997..468689(+) (comE/blpR) [Streptococcus pneumoniae strain serotype 4]
ATTGAAACGACGATTGAGAAACTCTTGAAGGAACATCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCA
ACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATCAGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGG
GGCTGGAAGTGGCTAGAAAGATTCGGGATCGAGACCCCTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATG
CCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGACTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTAT
CGAGACAGCCCTCCTCTATGCCAATAGTCAAGATAGTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTG
CCCAATTCCAGTATCCTTTTAAAGAGGTTTACTATCTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAG
ACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGAGGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCATCGCTCTTT
TCTCATCAATCCTGCAAATGTGGTGCATTTGGATAAGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGA
TCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCTATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-107)

LytTr DNA-binding domain (LytTR)

(136-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.07

99.13

0.526
  comE/comE1 Streptococcus equinus JB1

42.342

96.522

0.409
  comE/comE2 Streptococcus equinus JB1

36.681

99.565

0.365
  comE Streptococcus infantis strain Atu-4

35.931

100

0.361

Multiple sequence alignment