Detailed information NTG0099131

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SP4011_RS09160
• Genome accession: NZ_AP026968
• Coordinates: 1809875..1810612 (-)
• Length: 245 a.a.
• NCBI ID: WP_338618937.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1804875..1815612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS09130	-	1805615..1806226 (-)	612	WP_000394033.1	CPBP family intramembrane glutamic endopeptidase	-
SP4011_RS09135 (SP4011_17630)	blpZ	1806256..1806504 (-)	249	WP_119942870.1	immunity protein BlpZ	-
SP4011_RS09140	-	1806546..1807235 (-)	690	WP_338618932.1	lysostaphin resistance A-like protein	-
SP4011_RS09145 (SP4011_17650)	-	1807320..1807724 (-)	405	WP_338618933.1	immunity protein	-
SP4011_RS09155	-	1808512..1809861 (-)	1350	WP_338618936.1	sensor histidine kinase	-
SP4011_RS09160 (SP4011_17690)	comE/blpR	1809875..1810612 (-)	738	WP_338618937.1	response regulator transcription factor	Regulator
SP4011_RS09165 (SP4011_17700)	-	1810908..1811237 (+)	330	WP_000132586.1	hypothetical protein	-
SP4011_RS09170 (SP4011_17710)	-	1811300..1812349 (-)	1050	WP_016399209.1	ABC transporter permease	-
SP4011_RS09175 (SP4011_17720)	pptA	1812346..1813077 (-)	732	WP_016399210.1	ABC transporter ATP-binding protein	Regulator
SP4011_RS09180 (SP4011_17730)	-	1813145..1813555 (+)	411	WP_057487502.1	HIT family protein	-
SP4011_RS09185 (SP4011_17740)	-	1813565..1813852 (+)	288	WP_000777754.1	hypothetical protein	-
SP4011_RS09190 (SP4011_17750)	dnaJ	1814131..1815270 (-)	1140	WP_050275809.1	molecular chaperone DnaJ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28812.99 Da
• Isoelectric Point: 6.7693

>NTDB_id=99131 SP4011_RS09160 WP_338618937.1 1809875..1810612(-) (comE/blpR) [Streptococcus parapneumoniae strain SP4011]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEKFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQHPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=99131 SP4011_RS09160 WP_338618937.1 1809875..1810612(-) (comE/blpR) [Streptococcus parapneumoniae strain SP4011]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTTTTGAAGGAACA
TCATATCACTCCCAGTTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGGGCGCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGAAATTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGTTTTTACTTTAAATCAAAATTTGCCCAATTCCAGCATCCTTTTAAAGAGGTTTATTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACGGACAGGTTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTGCACTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.733	99.184	0.543
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	39.256	98.776	0.388
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363