Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SP4011_RS04605 Genome accession   NZ_AP026968
Coordinates   894829..895566 (+) Length   245 a.a.
NCBI ID   WP_023943094.1    Uniprot ID   V8I8A0
Organism   Streptococcus parapneumoniae strain SP4011     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 889829..900566
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS04585 (SP4011_08390) - 889911..891014 (+) 1104 WP_338620092.1 glycosyltransferase -
  SP4011_RS04590 (SP4011_08400) - 891016..892002 (+) 987 WP_173270238.1 glycosyltransferase -
  SP4011_RS04595 (SP4011_08410) - 892018..893487 (+) 1470 WP_050389933.1 O-antigen polysaccharide polymerase Wzy family protein -
  SP4011_RS04600 (SP4011_08420) - 893480..894514 (+) 1035 WP_112444069.1 prephenate dehydratase -
  SP4011_RS04605 (SP4011_08430) mecA 894829..895566 (+) 738 WP_023943094.1 adaptor protein MecA Regulator
  SP4011_RS04610 (SP4011_08440) - 895717..897003 (+) 1287 WP_020901496.1 homoserine dehydrogenase -
  SP4011_RS04615 (SP4011_08450) thrB 897005..897874 (+) 870 WP_050302699.1 homoserine kinase -
  SP4011_RS04620 (SP4011_08460) msrB 898134..899072 (+) 939 WP_338620093.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28408.17 Da        Isoelectric Point: 3.9879

>NTDB_id=99113 SP4011_RS04605 WP_023943094.1 894829..895566(+) (mecA) [Streptococcus parapneumoniae strain SP4011]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAQTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=99113 SP4011_RS04605 WP_023943094.1 894829..895566(+) (mecA) [Streptococcus parapneumoniae strain SP4011]
ATGAAAATGAAACAAATTAGTGATACAACTTTGAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGCATGGAGAT
TGCTGACTTTCTTGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCGCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCGGATAAAACTAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAAGAAGAGCAGGAACAGGCTGAACAAGAAGCTGAGAGCAAGAAAGAGCCCTATATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCCAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGACATTGAAAATCATCCAAGTCCATATCCAGCATGGCTTTTGGCCCGTATGCGCGAGT
TTGCGGATGATAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGATGAATCACGATGCAGTACTTAAT
CTGCAAAAGATTGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB V8I8A0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

98.776

100

0.988
  mecA Streptococcus pneumoniae D39

98.776

100

0.988
  mecA Streptococcus pneumoniae R6

98.776

100

0.988
  mecA Streptococcus pneumoniae TIGR4

98.367

100

0.984
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

47.755

100

0.478

Multiple sequence alignment