Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R8568_RS04760 Genome accession   NZ_AP026931
Coordinates   939899..940603 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain PZ900701541     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 934899..945603
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8568_RS04740 (PC1520_09500) coaC 935188..935739 (-) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -
  R8568_RS04745 (PC1520_09510) coaB 935751..936440 (-) 690 WP_000699531.1 phosphopantothenate--cysteine ligase -
  R8568_RS04750 (PC1520_09520) - 936670..938340 (+) 1671 WP_000845295.1 formate--tetrahydrofolate ligase -
  R8568_RS04755 (PC1520_09530) mutY 938669..939844 (+) 1176 WP_000886144.1 A/G-specific adenine glycosylase -
  R8568_RS04760 (PC1520_09540) micA 939899..940603 (+) 705 WP_000722076.1 response regulator YycF Regulator
  R8568_RS04765 (PC1520_09550) micB 940596..941945 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R8568_RS04770 (PC1520_09560) vicX 941947..942756 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R8568_RS04775 (PC1520_09570) relB 942847..943089 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R8568_RS04780 (PC1520_09580) - 943091..943345 (+) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R8568_RS04785 (PC1520_09590) - 943392..944135 (+) 744 WP_000731133.1 potassium channel family protein -
  R8568_RS04790 (PC1520_09600) - 944424..945410 (-) 987 WP_000204731.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=98812 R8568_RS04760 WP_000722076.1 939899..940603(+) (micA) [Streptococcus pneumoniae strain PZ900701541]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=98812 R8568_RS04760 WP_000722076.1 939899..940603(+) (micA) [Streptococcus pneumoniae strain PZ900701541]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment