Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R8568_RS04265 Genome accession   NZ_AP026931
Coordinates   847695..848432 (+) Length   245 a.a.
NCBI ID   WP_317640933.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900701541     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 842695..853432
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8568_RS04245 (PC1520_08450) - 842892..843995 (+) 1104 WP_000225904.1 glycosyltransferase -
  R8568_RS04250 (PC1520_08460) - 843997..844983 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  R8568_RS04255 (PC1520_08470) - 844999..846432 (+) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  R8568_RS04260 (PC1520_08480) - 846461..847495 (+) 1035 WP_000461498.1 hypothetical protein -
  R8568_RS04265 (PC1520_08490) mecA 847695..848432 (+) 738 WP_317640933.1 adaptor protein MecA Regulator
  R8568_RS04270 (PC1520_08500) - 848583..849869 (+) 1287 WP_000216386.1 homoserine dehydrogenase -
  R8568_RS04275 (PC1520_08510) thrB 849871..850740 (+) 870 WP_000692438.1 homoserine kinase -
  R8568_RS04280 (PC1520_08520) - 850816..850968 (+) 153 WP_001835993.1 hypothetical protein -
  R8568_RS04285 (PC1520_08530) msrB 851035..851973 (+) 939 WP_000818200.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28305.09 Da        Isoelectric Point: 4.0199

>NTDB_id=98810 R8568_RS04265 WP_317640933.1 847695..848432(+) (mecA) [Streptococcus pneumoniae strain PZ900701541]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELSKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=98810 R8568_RS04265 WP_317640933.1 847695..848432(+) (mecA) [Streptococcus pneumoniae strain PZ900701541]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTTCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTCCAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482
  mecA Streptococcus thermophilus LMG 18311

46.988

100

0.478

Multiple sequence alignment