Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC/comC2   Type   Regulator
Locus tag   R8623_RS10870 Genome accession   NZ_AP026928
Coordinates   2095542..2095667 (-) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain PZ900700406     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context


Location: 2090542..2100667
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8623_RS10840 - 2090880..2092483 (-) 1604 Protein_2096 YhgE/Pip family protein -
  R8623_RS10845 (PC0401_20800) - 2092662..2093204 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  R8623_RS10860 (PC0401_20810) comE 2093447..2094199 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R8623_RS10865 (PC0401_20820) comD/comD2 2094196..2095521 (-) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  R8623_RS10870 (PC0401_20830) comC/comC2 2095542..2095667 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  R8623_RS10880 (PC0401_20840) rlmH 2095949..2096428 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R8623_RS10885 (PC0401_20850) htrA 2096611..2097792 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  R8623_RS10890 (PC0401_20860) spo0J 2097850..2098608 (+) 759 WP_000410385.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence


Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=98634 R8623_RS10870 WP_000799694.1 2095542..2095667(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700406]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=98634 R8623_RS10870 WP_000799694.1 2095542..2095667(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700406]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains


Predicted by InterproScan.

(1-29)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976

  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976

  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78

  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78

  comC Streptococcus mitis SK321

75.61

100

0.756

  comC Streptococcus mitis NCTC 12261

60

97.561

0.585


Multiple sequence alignment