Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   R8623_RS10865 Genome accession   NZ_AP026928
Coordinates   2094196..2095521 (-) Length   441 a.a.
NCBI ID   WP_024477997.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700406     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2089196..2100521
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8623_RS10840 - 2090880..2092483 (-) 1604 Protein_2096 YhgE/Pip family protein -
  R8623_RS10845 (PC0401_20800) - 2092662..2093204 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  R8623_RS10860 (PC0401_20810) comE 2093447..2094199 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R8623_RS10865 (PC0401_20820) comD/comD2 2094196..2095521 (-) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  R8623_RS10870 (PC0401_20830) comC/comC2 2095542..2095667 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  R8623_RS10880 (PC0401_20840) rlmH 2095949..2096428 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R8623_RS10885 (PC0401_20850) htrA 2096611..2097792 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  R8623_RS10890 (PC0401_20860) spo0J 2097850..2098608 (+) 759 WP_000410385.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51489.09 Da        Isoelectric Point: 7.5816

>NTDB_id=98633 R8623_RS10865 WP_024477997.1 2094196..2095521(-) (comD/comD2) [Streptococcus pneumoniae strain PZ900700406]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYIFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYFYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=98633 R8623_RS10865 WP_024477997.1 2094196..2095521(-) (comD/comD2) [Streptococcus pneumoniae strain PZ900700406]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACATTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACTTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae Rx1

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae D39

96.372

100

0.964
  comD/comD1 Streptococcus pneumoniae R6

96.372

100

0.964
  comD Streptococcus mitis SK321

91.61

100

0.916
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment