Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ACJWMC_RS09410 Genome accession   NZ_CP177181
Coordinates   2014284..2015027 (-) Length   247 a.a.
NCBI ID   WP_002891963.1    Uniprot ID   J7T567
Organism   Streptococcus salivarius strain MRD1919     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2009284..2020027
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACJWMC_RS09390 - 2009600..2010799 (-) 1200 WP_037598503.1 argininosuccinate synthase -
  ACJWMC_RS09395 - 2011417..2012094 (+) 678 WP_002890056.1 helix-turn-helix domain-containing protein -
  ACJWMC_RS09400 - 2012091..2013056 (+) 966 WP_002890057.1 IS3 family transposase -
  ACJWMC_RS09405 tnpA 2013272..2013745 (-) 474 WP_002891962.1 IS200/IS605 family transposase -
  ACJWMC_RS09410 comE/blpR 2014284..2015027 (-) 744 WP_002891963.1 response regulator transcription factor Regulator
  ACJWMC_RS09415 - 2015029..2016345 (-) 1317 WP_002891964.1 GHKL domain-containing protein -
  ACJWMC_RS09420 - 2016366..2017646 (-) 1281 WP_002891965.1 hypothetical protein -
  ACJWMC_RS09425 - 2017668..2018558 (-) 891 WP_002891966.1 hypothetical protein -
  ACJWMC_RS09430 - 2018614..2019921 (-) 1308 WP_037598506.1 GHKL domain-containing protein -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28594.86 Da        Isoelectric Point: 6.5007

>NTDB_id=969754 ACJWMC_RS09410 WP_002891963.1 2014284..2015027(-) (comE/blpR) [Streptococcus salivarius strain MRD1919]
MNIYILEDDLMQQTRISDIIRELVSEGTFSVRKLEVFSKPHKLLSSINEKGNHQVFLLDIDIDGERKKGLEVASEIRQQD
ANAVIIFVTTHSEFAPISFKYKVSALDFIDKTVSNAEFKQQLKQTLTFVNQKVGDVDDDEIFVFETAQSRIQVPMRDIYY
FATAVTPHKVMLITKTERLEFYANLGDITSVNKKLFSCHRSFLVNLDNISRIDKTQLMIYFENDDSCPVSRLKMKALLKK
WSEVKEH

Nucleotide


Download         Length: 744 bp        

>NTDB_id=969754 ACJWMC_RS09410 WP_002891963.1 2014284..2015027(-) (comE/blpR) [Streptococcus salivarius strain MRD1919]
ATGAATATTTACATTTTAGAAGATGACTTAATGCAGCAAACACGTATTAGTGACATCATCAGAGAATTGGTTTCAGAGGG
CACGTTTTCCGTACGAAAACTTGAAGTTTTTTCTAAACCCCACAAACTATTGTCCAGTATAAACGAGAAGGGTAACCATC
AGGTTTTCCTTTTGGATATTGATATTGATGGTGAGCGAAAGAAGGGGCTAGAAGTCGCCTCAGAAATTCGCCAACAAGAT
GCTAATGCGGTTATTATTTTTGTGACAACTCACTCAGAGTTTGCACCGATTAGTTTTAAATACAAGGTTTCTGCACTAGA
TTTTATTGATAAGACAGTTTCTAATGCAGAGTTCAAACAACAACTAAAACAAACATTGACTTTTGTGAATCAAAAAGTTG
GAGATGTGGATGATGATGAGATATTTGTGTTTGAAACAGCACAGTCTCGAATCCAAGTCCCTATGAGAGATATTTATTAT
TTTGCGACTGCTGTGACACCTCATAAGGTGATGCTGATTACCAAAACAGAGCGTTTGGAGTTTTATGCCAATCTTGGAGA
TATTACTTCGGTGAATAAAAAACTCTTTTCTTGTCATCGCTCGTTTTTAGTTAATTTGGATAATATTTCTCGTATTGATA
AGACTCAGTTGATGATTTACTTTGAAAATGACGATTCTTGTCCAGTTTCACGTTTGAAAATGAAGGCCTTGCTTAAAAAA
TGGTCTGAGGTAAAAGAACATTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7T567

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

47.5

97.166

0.462
  comE/comE2 Streptococcus equinus JB1

43.265

99.19

0.429
  comE/comE1 Streptococcus equinus JB1

40.083

97.976

0.393
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.039

100

0.393
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.039

100

0.393